Abstract
Oxatropanes from oxiranes: An expedient assembly of the compact platensimycin core is described. The synthetic approach relies on a Suzuki cross-coupling, a late-stage dearomatization reaction, and a copper-catalyzed vinyl oxirane ring expansion for accessing the oxatropane moiety of the natural product.
Original language | English (US) |
---|---|
Pages (from-to) | 8543-8546 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 48 |
Issue number | 45 |
DOIs | |
State | Published - Oct 26 2009 |
Keywords
- Copper
- Natural products
- Oxiranes
- Platensimycin
- Total synthesis
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)