A computational framework for post-TAVR cardiac conduction abnormality (CCA) risk assessment in patient-specific anatomy

Symon Reza, Matteo Bianchi, Brandon Kovarovic, Salwa Anam, Marvin J. Slepian, Ashraf Hamdan, Rami Haj-Ali, Danny Bluestein

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Cardiac conduction abnormality (CCA)- one of the major persistent complications associated with transcatheter aortic valve replacement (TAVR) may lead to permanent pacemaker implantation. Localized stresses exerted by the device frame on the membranous septum (MS) which lies between the aortic annulus and the bundle of His, may disturb the cardiac conduction and cause the resultant CCA. We hypothesize that the area-weighted average maximum principal logarithmic strain (AMPLS) in the MS region can predict the risk of CCA following TAVR. Methods: Rigorous finite element-based analysis was conducted in two patients (Balloon expandable TAVR recipients) to assess post-TAVR CCA risk. Following the procedure one of the patients required permanent pacemaker (PPM) implantation while the other did not (control case). Patient-specific aortic root was modeled, MS was identified from the CT image, and the TAVR deployment was simulated. Mechanical factors in the MS region such as logarithmic strain, contact force, contact pressure, contact pressure index (CPI) and their time history during the TAVR deployment; and anatomical factors such as MS length, implantation depth, were analyzed. Results: Maximum AMPLS (0.47 and 0.37, respectively), contact force (0.92 N and 0.72 N, respectively), and CPI (3.99 and 2.86, respectively) in the MS region were significantly elevated in the PPM patient as compared to control patient. Conclusion: Elevated stresses generated by TAVR devices during deployment appear to correlate with CCA risk, with AMPLS in the MS region emerging as a strong predictor that could be used for preprocedural planning in order to minimize CCA risk.

Original languageEnglish (US)
Pages (from-to)1305-1317
Number of pages13
JournalArtificial Organs
Volume46
Issue number7
DOIs
StatePublished - Jul 2022

Keywords

  • aortic stenosis
  • cardiac conduction abnormality
  • finite element analysis
  • permanent pacemaker
  • permanent pacemaker implantation
  • transcatheter aortic valve implantation
  • transcatheter aortic valve replacement

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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