A complex rearrangement of chromosome 7 in human astrocytoma

Anjan Misra; Malgorzata Pellarin; Joan R. Shapiro; Burt G. Feuerstein

doi:10.1016/j.cancergencyto.2003.09.017

A complex rearrangement of chromosome 7 in human astrocytoma

Anjan Misra, Malgorzata Pellarin, Joan R. Shapiro, Burt G. Feuerstein

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Abstract

Chromosome 7 is a frequent site of cytogenetic aberrations in human astrocytomas. One region that is often targeted in human astrocytomas is on 7p. The U251 human glioblastoma cell line has a region of gain of genetic material on 7p similar to that seen in human astrocytomas. We used several cytogenetic techniques to study chromosome 7 in U251 cells and identified a complex rearrangement that accounts for gain of chromosome 7 genetic material in the cell line. The characteristic rearrangement suggests a mechanism leading to 7p gain in primary grade IV astrocytomas.

Original language	English (US)
Pages (from-to)	162-170
Number of pages	9
Journal	Cancer Genetics and Cytogenetics
Volume	151
Issue number	2
DOIs	https://doi.org/10.1016/j.cancergencyto.2003.09.017
State	Published - Jun 2004

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1016/j.cancergencyto.2003.09.017

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@article{626eadb523c04fe1868ecac81db0e0ea,

title = "A complex rearrangement of chromosome 7 in human astrocytoma",

abstract = "Chromosome 7 is a frequent site of cytogenetic aberrations in human astrocytomas. One region that is often targeted in human astrocytomas is on 7p. The U251 human glioblastoma cell line has a region of gain of genetic material on 7p similar to that seen in human astrocytomas. We used several cytogenetic techniques to study chromosome 7 in U251 cells and identified a complex rearrangement that accounts for gain of chromosome 7 genetic material in the cell line. The characteristic rearrangement suggests a mechanism leading to 7p gain in primary grade IV astrocytomas.",

author = "Anjan Misra and Malgorzata Pellarin and Shapiro, {Joan R.} and Feuerstein, {Burt G.}",

note = "Funding Information: We acknowledge Richard Segraves and Drs. Donna Albertson and Daniel Pinkel for help with arrays, Dr. Thomas Reid from the NIH and Research Genetics (now Invitrogen, Carlsbad, CA) for chromosome 7 BAC clones, Dr. Kent Opheim for help with SKY analysis, and Pamela Derish, Susan Eastwood, Sharon Reynolds and Dr. Edward Pan for editorial support. The work was supported by the National Institutes of Health grants CA85799, NS42927, and NS40958 and by the North American Brain Tumor Consortium and National Brain Tumor Foundation. ",

year = "2004",

month = jun,

doi = "10.1016/j.cancergencyto.2003.09.017",

language = "English (US)",

volume = "151",

pages = "162--170",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

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AU - Misra, Anjan

AU - Pellarin, Malgorzata

AU - Shapiro, Joan R.

AU - Feuerstein, Burt G.

N1 - Funding Information: We acknowledge Richard Segraves and Drs. Donna Albertson and Daniel Pinkel for help with arrays, Dr. Thomas Reid from the NIH and Research Genetics (now Invitrogen, Carlsbad, CA) for chromosome 7 BAC clones, Dr. Kent Opheim for help with SKY analysis, and Pamela Derish, Susan Eastwood, Sharon Reynolds and Dr. Edward Pan for editorial support. The work was supported by the National Institutes of Health grants CA85799, NS42927, and NS40958 and by the North American Brain Tumor Consortium and National Brain Tumor Foundation.

PY - 2004/6

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N2 - Chromosome 7 is a frequent site of cytogenetic aberrations in human astrocytomas. One region that is often targeted in human astrocytomas is on 7p. The U251 human glioblastoma cell line has a region of gain of genetic material on 7p similar to that seen in human astrocytomas. We used several cytogenetic techniques to study chromosome 7 in U251 cells and identified a complex rearrangement that accounts for gain of chromosome 7 genetic material in the cell line. The characteristic rearrangement suggests a mechanism leading to 7p gain in primary grade IV astrocytomas.

AB - Chromosome 7 is a frequent site of cytogenetic aberrations in human astrocytomas. One region that is often targeted in human astrocytomas is on 7p. The U251 human glioblastoma cell line has a region of gain of genetic material on 7p similar to that seen in human astrocytomas. We used several cytogenetic techniques to study chromosome 7 in U251 cells and identified a complex rearrangement that accounts for gain of chromosome 7 genetic material in the cell line. The characteristic rearrangement suggests a mechanism leading to 7p gain in primary grade IV astrocytomas.

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JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 2

ER -

A complex rearrangement of chromosome 7 in human astrocytoma

Abstract

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