A comparative study of sodium bicarbonate and carbicarb in the treatment of metabolic acidosis induced by Hemorrhagic Shock

Ian D. Klepper; Richard F. Kucera; Neal B. Kindig; Duane L. Sherrill; Giles F. Filley

doi:10.1016/0883-9441(88)90110-4

A comparative study of sodium bicarbonate and carbicarb in the treatment of metabolic acidosis induced by Hemorrhagic Shock

Ian D. Klepper, Richard F. Kucera, Neal B. Kindig, Duane L. Sherrill, Giles F. Filley

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

"Carbicarb" (CBC; International Medication Systems, South El Monte, CA) is a new alkalinizing agent composed of equimolar NaHCO₃ and NasCO₃, each salt 1 3 mol/L in concentration. We compared CBC with 1 mol/L NaHCO₃ in the treatment of lactic acidosis in dogs with hemorrhagic shock. Carbon dioxide excretion from the lungs (CO₂ output), along with arterial and mixed venous PCO₂, increased significantly less with CBC than with NaHCO₃ for 30 minutes following therapy. Arterial pH increased more with CBC than with NaHCO₃ for the first five minutes of therapy. Both alkaline solutions produced increases in mean arterial pressure, cardiac output, oxygen delivery, and oxygen consumption. These increases were not significantly different for the two solutions. CBC injection did not result in any damage to RBCs or to the endothelium of peripheral veins.

Original language	English (US)
Pages (from-to)	256-261
Number of pages	6
Journal	Journal of Critical Care
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/0883-9441(88)90110-4
State	Published - Dec 1988
Externally published	Yes

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

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10.1016/0883-9441(88)90110-4

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title = "A comparative study of sodium bicarbonate and carbicarb in the treatment of metabolic acidosis induced by Hemorrhagic Shock",

abstract = "{"}Carbicarb{"} (CBC; International Medication Systems, South El Monte, CA) is a new alkalinizing agent composed of equimolar NaHCO3 and NasCO3, each salt 1 3 mol/L in concentration. We compared CBC with 1 mol/L NaHCO3 in the treatment of lactic acidosis in dogs with hemorrhagic shock. Carbon dioxide excretion from the lungs (CO2 output), along with arterial and mixed venous PCO2, increased significantly less with CBC than with NaHCO3 for 30 minutes following therapy. Arterial pH increased more with CBC than with NaHCO3 for the first five minutes of therapy. Both alkaline solutions produced increases in mean arterial pressure, cardiac output, oxygen delivery, and oxygen consumption. These increases were not significantly different for the two solutions. CBC injection did not result in any damage to RBCs or to the endothelium of peripheral veins.",

author = "Klepper, {Ian D.} and Kucera, {Richard F.} and Kindig, {Neal B.} and Sherrill, {Duane L.} and Filley, {Giles F.}",

note = "Funding Information: Sciences Center, Denver. Supported by the Department of Anesthesiology, The Webb-Waring Lung Institute, and Fitzsimons Army Medical Center. The opinions or assertions contained herein are the private views of the authors and are not to be construed as oficial or as reflecting the views of the Department of the Army or the Department of Defense. Address reprint requests to Giles F. Filley, MD, Webb-Waring Lung Institute, 4200 E 9th Ave. Denver, CO 80262. o I988 by Grune & Stratton, Inc.",

year = "1988",

month = dec,

doi = "10.1016/0883-9441(88)90110-4",

language = "English (US)",

volume = "3",

pages = "256--261",

journal = "Journal of Critical Care",

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T1 - A comparative study of sodium bicarbonate and carbicarb in the treatment of metabolic acidosis induced by Hemorrhagic Shock

AU - Klepper, Ian D.

AU - Kucera, Richard F.

AU - Kindig, Neal B.

AU - Sherrill, Duane L.

AU - Filley, Giles F.

N1 - Funding Information: Sciences Center, Denver. Supported by the Department of Anesthesiology, The Webb-Waring Lung Institute, and Fitzsimons Army Medical Center. The opinions or assertions contained herein are the private views of the authors and are not to be construed as oficial or as reflecting the views of the Department of the Army or the Department of Defense. Address reprint requests to Giles F. Filley, MD, Webb-Waring Lung Institute, 4200 E 9th Ave. Denver, CO 80262. o I988 by Grune & Stratton, Inc.

PY - 1988/12

Y1 - 1988/12

N2 - "Carbicarb" (CBC; International Medication Systems, South El Monte, CA) is a new alkalinizing agent composed of equimolar NaHCO3 and NasCO3, each salt 1 3 mol/L in concentration. We compared CBC with 1 mol/L NaHCO3 in the treatment of lactic acidosis in dogs with hemorrhagic shock. Carbon dioxide excretion from the lungs (CO2 output), along with arterial and mixed venous PCO2, increased significantly less with CBC than with NaHCO3 for 30 minutes following therapy. Arterial pH increased more with CBC than with NaHCO3 for the first five minutes of therapy. Both alkaline solutions produced increases in mean arterial pressure, cardiac output, oxygen delivery, and oxygen consumption. These increases were not significantly different for the two solutions. CBC injection did not result in any damage to RBCs or to the endothelium of peripheral veins.

AB - "Carbicarb" (CBC; International Medication Systems, South El Monte, CA) is a new alkalinizing agent composed of equimolar NaHCO3 and NasCO3, each salt 1 3 mol/L in concentration. We compared CBC with 1 mol/L NaHCO3 in the treatment of lactic acidosis in dogs with hemorrhagic shock. Carbon dioxide excretion from the lungs (CO2 output), along with arterial and mixed venous PCO2, increased significantly less with CBC than with NaHCO3 for 30 minutes following therapy. Arterial pH increased more with CBC than with NaHCO3 for the first five minutes of therapy. Both alkaline solutions produced increases in mean arterial pressure, cardiac output, oxygen delivery, and oxygen consumption. These increases were not significantly different for the two solutions. CBC injection did not result in any damage to RBCs or to the endothelium of peripheral veins.

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A comparative study of sodium bicarbonate and carbicarb in the treatment of metabolic acidosis induced by Hemorrhagic Shock

Abstract

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