A compact fluorescence/circular dichroism dual-modality probe for detection, differentiation, and detoxification of multiple heavy metal ions via bond-cleavage cascade reactions

Junwei Chen, Na Wang, Hongjuan Tong, Chao Song, Huijuan Ma, Yajun Zhang, Feng Gao, Huan Xu, Wei Wang, Kaiyan Lou

Research output: Contribution to journalArticlepeer-review

Abstract

Selective detection of multiple analytes in a compact design with dual-modality and theranostic features presents great challenges. Herein, we wish to report a coumarin-thiazolidine masked D-penicillamine based dual-modality fluorescent probe COU-DPA-1 for selective detection, differentiation, and detoxification of multiple heavy metal ions (Ag+, Hg2+, Cu2+). The probe shows divergent fluorescence (FL) /circular dichroism (CD) responses via divergent bond-cleavage cascade reactions (metal ion promoted C-S cleavage and hydrolysis at two distinctive cleavage sites): FL “turn-off” and CD “turn-on” for Ag+ (no hydrolysis), FL “turn-on” and CD “turn-off” for Hg2+ (imine hydrolysis), and FL “self-threshold ratiometric” and CD “turn-off” for excess Cu2+ (lactone and imine hydrolysis), providing the first example of a fluorescence/CD dual-modality probe for multiple species with complimentary responses. Moreover, the bond-cleavage cascade reactions also lead to the formation of D-penicillamine heavy metal ion complexes for potential detoxification treatments.

Original languageEnglish (US)
Pages (from-to)3876-3881
Number of pages6
JournalChinese Chemical Letters
Volume32
Issue number12
DOIs
StatePublished - Dec 2021
Externally publishedYes

Keywords

  • Cascade reaction
  • Circular dichroism
  • Detoxification
  • Divergent responses
  • Dual-modality
  • Fluorescent probe
  • Heavy metal ions

ASJC Scopus subject areas

  • Chemistry(all)

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