A community-based, cross-sectional study of hrHPV DNA self-sampling-based cervical cancer screening in rural Karnataka, India

Prajakta Adsul, Vijaya Srinivas, Savitha Gowda, Shivamma Nayaka, Rashmi Pramathesh, Kavitha Chandrappa, Anisa Khan, Poornima Jayakrishna, Purnima Madhivanan

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objective: To examine the feasibility of implementing a high-risk HPV (hrHPV) DNA-based screening program for cervical cancer and the prevalence of hrHPV DNA-positive women in a community setting in rural India. Methods: A cross-sectional study was conducted at the community level in the Hunsur taluk of the Mysore district from January to August 2016. Cervical cancer screening was conducted with self-collected vaginal samples that were analyzed using the Hybrid Capture 2 (HC2) assay (Qiagen, USA). Results: The majority of participants were aged 30–39 years, with no formal schooling, from a lower caste, and lived below an annual household income of US$1499. After group health education and one-on-one counseling, a total of 473 women underwent self-sampling. Of these, 36 (7.6%) were positive for hrHPV and only 24 (66.6%) underwent follow-up diagnostic triaging. Cancer was detected in two women, who were referred to appropriate healthcare facilities for further treatment. Conclusion: Implementation of hrHPV DNA-based screening tests using self-sampling can be feasible in rural settings in India. However, substantial resources are required for providing health education and one-on-one counseling to inform asymptomatic women about the benefits of testing and, more importantly, to improve compliance with follow-up.

Original languageEnglish (US)
Pages (from-to)170-176
Number of pages7
JournalInternational Journal of Gynecology and Obstetrics
Volume146
Issue number2
DOIs
StatePublished - Aug 2019

Keywords

  • Cervical cancer
  • Cross-sectional study
  • Demonstration study
  • HPV DNA
  • Implementation
  • Screening
  • Self-sampling

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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