@article{91da608df1384decbead884797938790,
title = "A community-based, cross-sectional study of hrHPV DNA self-sampling-based cervical cancer screening in rural Karnataka, India",
abstract = "Objective: To examine the feasibility of implementing a high-risk HPV (hrHPV) DNA-based screening program for cervical cancer and the prevalence of hrHPV DNA-positive women in a community setting in rural India. Methods: A cross-sectional study was conducted at the community level in the Hunsur taluk of the Mysore district from January to August 2016. Cervical cancer screening was conducted with self-collected vaginal samples that were analyzed using the Hybrid Capture 2 (HC2) assay (Qiagen, USA). Results: The majority of participants were aged 30–39 years, with no formal schooling, from a lower caste, and lived below an annual household income of US$1499. After group health education and one-on-one counseling, a total of 473 women underwent self-sampling. Of these, 36 (7.6%) were positive for hrHPV and only 24 (66.6%) underwent follow-up diagnostic triaging. Cancer was detected in two women, who were referred to appropriate healthcare facilities for further treatment. Conclusion: Implementation of hrHPV DNA-based screening tests using self-sampling can be feasible in rural settings in India. However, substantial resources are required for providing health education and one-on-one counseling to inform asymptomatic women about the benefits of testing and, more importantly, to improve compliance with follow-up.",
keywords = "Cervical cancer, Cross-sectional study, Demonstration study, HPV DNA, Implementation, Screening, Self-sampling",
author = "Prajakta Adsul and Vijaya Srinivas and Savitha Gowda and Shivamma Nayaka and Rashmi Pramathesh and Kavitha Chandrappa and Anisa Khan and Poornima Jayakrishna and Purnima Madhivanan",
note = "Funding Information: Research reported in this publicaD鸀on was supported by the Fogarty InternaD鸀onal Center at the NaD鸀onal InsD鸀tutes of Health (Gra-nt num bers TW009338 and TW010540). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NaD鸀onal InsD鸀tutes of Health. The Public Health Research InsD鸀tute of India received the hrHPV tesD鸀ng equipment in kind from 18. Qiagen for the purposes of this research study. The authors thank Dr Somya, Dr Jyothi, Mr Javali, and Dr Elizabeth Frank for their help in coordinaD鸀ng logisD鸀cs for this study. Funding Information: Research reported in this publication was supported by the Fogarty International Center at the National Institutes of Health (Grant numbers TW009338 and TW010540). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The Public Health Research Institute of India received the hrHPV testing equipment in kind from Qiagen for the purposes of this research study. The authors thank Dr Somya, Dr Jyothi, Mr Javali, and Dr Elizabeth Frank for their help in coordinating logistics for this study. Publisher Copyright: {\textcopyright} 2019 International Federation of Gynecology and Obstetrics",
year = "2019",
month = aug,
doi = "10.1002/ijgo.12859",
language = "English (US)",
volume = "146",
pages = "170--176",
journal = "International Journal of Gynecology and Obstetrics",
issn = "0020-7292",
publisher = "Elsevier Ireland Ltd",
number = "2",
}