A clinical and histopathological study of François-Neetens speckled corneal dystrophy

Don H. Nicholson; W. Richard Green; Harold E. Cross; Kenneth R. Kenyon; Darcy Massof

doi:10.1016/0002-9394(77)90566-9

A clinical and histopathological study of François-Neetens speckled corneal dystrophy

Don H. Nicholson, W. Richard Green, Harold E. Cross, Kenneth R. Kenyon, Darcy Massof

Ophthalmology and Vision Sciences

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A 57-year-old black man had François-Neetens speckled dystrophy of the cornea and orbital phycomycosis. Examination of family members confirmed an autosomal-dominant pattern of inheritance. Light and electron microscopic study of the cornea of a blind eye disclosed that the corneal opacities were represented by swollen, vacuolated keratocytes filled with histochemically demonstrable acid mucopolysaccharide and complex lipids. Thus, this dystrophy may represent a dominantly inherited metabolic disorder confined to the cornea.

Original language	English (US)
Pages (from-to)	554-560
Number of pages	7
Journal	American Journal of Ophthalmology
Volume	83
Issue number	4
DOIs	https://doi.org/10.1016/0002-9394(77)90566-9
State	Published - Apr 1977

ASJC Scopus subject areas

Ophthalmology

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10.1016/0002-9394(77)90566-9

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title = "A clinical and histopathological study of Fran{\c c}ois-Neetens speckled corneal dystrophy",

abstract = "A 57-year-old black man had Fran{\c c}ois-Neetens speckled dystrophy of the cornea and orbital phycomycosis. Examination of family members confirmed an autosomal-dominant pattern of inheritance. Light and electron microscopic study of the cornea of a blind eye disclosed that the corneal opacities were represented by swollen, vacuolated keratocytes filled with histochemically demonstrable acid mucopolysaccharide and complex lipids. Thus, this dystrophy may represent a dominantly inherited metabolic disorder confined to the cornea.",

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AU - Green, W. Richard

AU - Cross, Harold E.

AU - Kenyon, Kenneth R.

AU - Massof, Darcy

PY - 1977/4

Y1 - 1977/4

N2 - A 57-year-old black man had François-Neetens speckled dystrophy of the cornea and orbital phycomycosis. Examination of family members confirmed an autosomal-dominant pattern of inheritance. Light and electron microscopic study of the cornea of a blind eye disclosed that the corneal opacities were represented by swollen, vacuolated keratocytes filled with histochemically demonstrable acid mucopolysaccharide and complex lipids. Thus, this dystrophy may represent a dominantly inherited metabolic disorder confined to the cornea.

AB - A 57-year-old black man had François-Neetens speckled dystrophy of the cornea and orbital phycomycosis. Examination of family members confirmed an autosomal-dominant pattern of inheritance. Light and electron microscopic study of the cornea of a blind eye disclosed that the corneal opacities were represented by swollen, vacuolated keratocytes filled with histochemically demonstrable acid mucopolysaccharide and complex lipids. Thus, this dystrophy may represent a dominantly inherited metabolic disorder confined to the cornea.

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A clinical and histopathological study of François-Neetens speckled corneal dystrophy

Abstract

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