A bioactive seco-rosane diterpenoid from Vellozia candida

Ligia M.M. Valente; A. A.Leslie Gunatilaka; David G.I. Kingston; Maria L. Patitucci; Angelo C. Pinto

doi:10.1021/np960695a

A bioactive seco-rosane diterpenoid from Vellozia candida

Ligia M.M. Valente
, A. A.Leslie Gunatilaka
, David G.I. Kingston
, Maria L. Patitucci
, Angelo C. Pinto

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.

Original language	English (US)
Pages (from-to)	478-481
Number of pages	4
Journal	Journal Of Natural Products
Volume	60
Issue number	5
DOIs	https://doi.org/10.1021/np960695a
State	Published - 1997

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np960695a

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title = "A bioactive seco-rosane diterpenoid from Vellozia candida",

abstract = "Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.",

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year = "1997",

doi = "10.1021/np960695a",

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pages = "478--481",

journal = "Journal Of Natural Products",

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T1 - A bioactive seco-rosane diterpenoid from Vellozia candida

AU - Valente, Ligia M.M.

AU - Gunatilaka, A. A.Leslie

AU - Kingston, David G.I.

AU - Patitucci, Maria L.

AU - Pinto, Angelo C.

PY - 1997

Y1 - 1997

N2 - Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.

AB - Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.

UR - https://www.scopus.com/pages/publications/0030953715

UR - https://www.scopus.com/pages/publications/0030953715#tab=citedBy

U2 - 10.1021/np960695a

DO - 10.1021/np960695a

M3 - Article

C2 - 9170291

AN - SCOPUS:0030953715

SN - 0163-3864

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EP - 481

JO - Journal Of Natural Products

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ER -

A bioactive seco-rosane diterpenoid from Vellozia candida

Abstract

ASJC Scopus subject areas

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