A bioactive seco-rosane diterpenoid from Vellozia candida

Ligia M.M. Valente; A. A.Leslie Gunatilaka; David G.I. Kingston; Maria L. Patitucci; Angelo C. Pinto

doi:10.1021/np960695a

A bioactive seco-rosane diterpenoid from Vellozia candida

Ligia M.M. Valente, A. A.Leslie Gunatilaka, David G.I. Kingston, Maria L. Patitucci, Angelo C. Pinto

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15 Scopus citations

Abstract

Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.

Original language	English (US)
Pages (from-to)	478-481
Number of pages	4
Journal	Journal Of Natural Products
Volume	60
Issue number	5
DOIs	https://doi.org/10.1021/np960695a
State	Published - 1997

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np960695a

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title = "A bioactive seco-rosane diterpenoid from Vellozia candida",

abstract = "Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.",

author = "Valente, {Ligia M.M.} and Gunatilaka, {A. A.Leslie} and Kingston, {David G.I.} and Patitucci, {Maria L.} and Pinto, {Angelo C.}",

year = "1997",

doi = "10.1021/np960695a",

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journal = "Journal of Natural Products",

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AU - Valente, Ligia M.M.

AU - Gunatilaka, A. A.Leslie

AU - Kingston, David G.I.

AU - Patitucci, Maria L.

AU - Pinto, Angelo C.

PY - 1997

Y1 - 1997

N2 - Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.

AB - Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.

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A bioactive seco-rosane diterpenoid from Vellozia candida

Abstract

ASJC Scopus subject areas

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