TY - JOUR
T1 - A 6-year review of total parenteral nutrition use and association with late-onset acute respiratory distress syndrome among ventilated trauma victims
AU - Plurad, David
AU - Green, Donald
AU - Inaba, Kenji
AU - Belzberg, Howard
AU - Demetriades, Demetrios
AU - Rhee, Peter
PY - 2009/5
Y1 - 2009/5
N2 - Aim: To establish whether total parenteral nutrition (TPN) for ventilated trauma victims is associated with late-onset acute respiratory distress syndrome (ARDS) independent of ventilation and transfusion parameters. Method: Intensive care unit data over 6 years from a level I centre regarding all trauma victims ≥16 years old who underwent mechanical ventilation within the first 48 h of admission were examined. Patients were prospectively followed for late ARDS. Variables were examined for significant changes over time and independent associations with late ARDS were determined. Results: Of 2346 eligible patients among whom 404 (17.2%) were exposed to TPN, 192 (8.2%) met criteria for late ARDS. The incidence of late ARDS among those exposed to TPN was 28.7% (116/404) compared with 3.9% (76/1942) among those not so exposed. Adjustments for potential confounding associated risk factors were made. Conclusions: TPN administration is independently associated with late ARDS, and its use among critically ill trauma victims should be carefully scrutinised.
AB - Aim: To establish whether total parenteral nutrition (TPN) for ventilated trauma victims is associated with late-onset acute respiratory distress syndrome (ARDS) independent of ventilation and transfusion parameters. Method: Intensive care unit data over 6 years from a level I centre regarding all trauma victims ≥16 years old who underwent mechanical ventilation within the first 48 h of admission were examined. Patients were prospectively followed for late ARDS. Variables were examined for significant changes over time and independent associations with late ARDS were determined. Results: Of 2346 eligible patients among whom 404 (17.2%) were exposed to TPN, 192 (8.2%) met criteria for late ARDS. The incidence of late ARDS among those exposed to TPN was 28.7% (116/404) compared with 3.9% (76/1942) among those not so exposed. Adjustments for potential confounding associated risk factors were made. Conclusions: TPN administration is independently associated with late ARDS, and its use among critically ill trauma victims should be carefully scrutinised.
KW - Acute respiratory distress syndrome
KW - Mechanical ventilation
KW - Total parenteral nutrition
KW - Trauma
UR - http://www.scopus.com/inward/record.url?scp=67349282472&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349282472&partnerID=8YFLogxK
U2 - 10.1016/j.injury.2008.07.025
DO - 10.1016/j.injury.2008.07.025
M3 - Article
C2 - 19117556
AN - SCOPUS:67349282472
VL - 40
SP - 511
EP - 515
JO - Injury
JF - Injury
SN - 0020-1383
IS - 5
ER -