8q24 sequence variants in relation to prostate cancer risk among men of African descent: A case-control study

Marnita L. Benford; Tiva T. VanCleave; Nicole A. Lavender; Rick A. Kittles; La Creis R. Kidd

doi:10.1186/1471-2407-10-334

8q24 sequence variants in relation to prostate cancer risk among men of African descent: A case-control study

Marnita L. Benford, Tiva T. VanCleave, Nicole A. Lavender, Rick A. Kittles, La Creis R. Kidd

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Background: Human chromosome 8q24 has been implicated in prostate tumorigenesis.Methods: Consequently, we evaluated seven 8q24 sequence variants relative to prostate cancer (PCA) in a case-control study involving men of African descent. Genetic alterations were detected in germ-line DNA from 195 incident PCA cases and 531 controls using TaqMan polymerase chain reaction (PCR).Results: Inheritance of the 8q24 rs16901979 T allele corresponded to a 2.5-fold increase in the risk of developing PCA for our test group. These findings were validated using multifactor dimensionality reduction (MDR) and permutation testing (p = 0.038). The remaining 8q24 targets were not significantly related to PCA outcomes.Conclusions: Although compelling evidence suggests that the 8q24 rs16901979 locus may serve as an effective PCA predictor, our findings require additional evaluation in larger studies.

Original language	English (US)
Article number	334
Journal	BMC Cancer
Volume	10
DOIs	https://doi.org/10.1186/1471-2407-10-334
State	Published - Jun 28 2010
Externally published	Yes

ASJC Scopus subject areas

Oncology
Genetics
Cancer Research

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10.1186/1471-2407-10-334

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@article{f20a5ff8c82a416b84e6ca001d2b0e28,

title = "8q24 sequence variants in relation to prostate cancer risk among men of African descent: A case-control study",

abstract = "Background: Human chromosome 8q24 has been implicated in prostate tumorigenesis.Methods: Consequently, we evaluated seven 8q24 sequence variants relative to prostate cancer (PCA) in a case-control study involving men of African descent. Genetic alterations were detected in germ-line DNA from 195 incident PCA cases and 531 controls using TaqMan polymerase chain reaction (PCR).Results: Inheritance of the 8q24 rs16901979 T allele corresponded to a 2.5-fold increase in the risk of developing PCA for our test group. These findings were validated using multifactor dimensionality reduction (MDR) and permutation testing (p = 0.038). The remaining 8q24 targets were not significantly related to PCA outcomes.Conclusions: Although compelling evidence suggests that the 8q24 rs16901979 locus may serve as an effective PCA predictor, our findings require additional evaluation in larger studies.",

author = "Benford, {Marnita L.} and VanCleave, {Tiva T.} and Lavender, {Nicole A.} and Kittles, {Rick A.} and Kidd, {La Creis R.}",

note = "Funding Information: The authors thank the men of African descent for their participation in the current study. This study was supported in part by the NIH R03 CA128028, the James Graham Brown Cancer Center, and the Bucks for Brains {"}Our Highest Potential{"} in Cancer Research Endowment. The authors appreciate access to the Center for Genetics and Molecular Medicine (CGeMM) DNA Core Facility at the UofL, directed by Dr. Ron Gregg, for use of their high-throughput genotyp-ing facility. We also thank Andrew Marsh for editing this manuscript.",

year = "2010",

month = jun,

day = "28",

doi = "10.1186/1471-2407-10-334",

language = "English (US)",

volume = "10",

journal = "BMC Cancer",

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T1 - 8q24 sequence variants in relation to prostate cancer risk among men of African descent

T2 - A case-control study

AU - Benford, Marnita L.

AU - VanCleave, Tiva T.

AU - Lavender, Nicole A.

AU - Kittles, Rick A.

AU - Kidd, La Creis R.

N1 - Funding Information: The authors thank the men of African descent for their participation in the current study. This study was supported in part by the NIH R03 CA128028, the James Graham Brown Cancer Center, and the Bucks for Brains "Our Highest Potential" in Cancer Research Endowment. The authors appreciate access to the Center for Genetics and Molecular Medicine (CGeMM) DNA Core Facility at the UofL, directed by Dr. Ron Gregg, for use of their high-throughput genotyp-ing facility. We also thank Andrew Marsh for editing this manuscript.

PY - 2010/6/28

Y1 - 2010/6/28

N2 - Background: Human chromosome 8q24 has been implicated in prostate tumorigenesis.Methods: Consequently, we evaluated seven 8q24 sequence variants relative to prostate cancer (PCA) in a case-control study involving men of African descent. Genetic alterations were detected in germ-line DNA from 195 incident PCA cases and 531 controls using TaqMan polymerase chain reaction (PCR).Results: Inheritance of the 8q24 rs16901979 T allele corresponded to a 2.5-fold increase in the risk of developing PCA for our test group. These findings were validated using multifactor dimensionality reduction (MDR) and permutation testing (p = 0.038). The remaining 8q24 targets were not significantly related to PCA outcomes.Conclusions: Although compelling evidence suggests that the 8q24 rs16901979 locus may serve as an effective PCA predictor, our findings require additional evaluation in larger studies.

AB - Background: Human chromosome 8q24 has been implicated in prostate tumorigenesis.Methods: Consequently, we evaluated seven 8q24 sequence variants relative to prostate cancer (PCA) in a case-control study involving men of African descent. Genetic alterations were detected in germ-line DNA from 195 incident PCA cases and 531 controls using TaqMan polymerase chain reaction (PCR).Results: Inheritance of the 8q24 rs16901979 T allele corresponded to a 2.5-fold increase in the risk of developing PCA for our test group. These findings were validated using multifactor dimensionality reduction (MDR) and permutation testing (p = 0.038). The remaining 8q24 targets were not significantly related to PCA outcomes.Conclusions: Although compelling evidence suggests that the 8q24 rs16901979 locus may serve as an effective PCA predictor, our findings require additional evaluation in larger studies.

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8q24 sequence variants in relation to prostate cancer risk among men of African descent: A case-control study

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