@inproceedings{900b952753874a97b6293efdfce57ab9,
title = "4D Transcranial Acoustoelectric Imaging of Current Densities in a Human Head Phantom",
abstract = "A broad spectrum of brain disorders - from epilepsy to depression - are characterized by abnormal electrical conduction. Often, electroencephalography (EEG) is incapable of recording the complex dynamics behind these disorders due to poor spatial resolution. We are proposing transcranial acoustoelectric brain imaging (tABI) to overcome these limitations. tABI may be able to accurately resolve deep neuronal currents with high spatial resolution (< 3 mm). This specific study aimed to determine the sensitivity and resolution of an electrically active human brain phantom when transmitting ultrasound through a human cadaveric skull and recording electrical activity on the skull. 4D tABI accurately mapped deep, time-varying dipoles > 50 mm below the phantom surface with an axial resolution of ~3mm at 0.6 MHz. Current detection limits through the skull at biologically safe US intensities were <500μA - within range of the strongest induced neuronal currents in the human brain. Noninvasive detection of weak neural currents (<0.1mA/cm2) like those simulated with the phantom in this study would open the possibility to 4D tABI as a revolutionary modality for accurate, high resolution mapping of electrical signals in the human brain.",
keywords = "EEG, acoustoelectric, electrical brain mapping, epilepsy, fMRI, human brain imaging",
author = "Andres Barragan and Chet Preston and Alexander Alvarez and Ingram, {Charles P.} and {Kanti Bera}, Tushar and Witte, {Russell S.}",
note = "Funding Information: This work received funding support from the National Institutes of Health: R24MH109060, T32EB000809, T32HL007955, R25HD080811 Publisher Copyright: {\textcopyright} 2019 IEEE.; 2019 IEEE International Ultrasonics Symposium, IUS 2019 ; Conference date: 06-10-2019 Through 09-10-2019",
year = "2019",
month = oct,
doi = "10.1109/ULTSYM.2019.8926286",
language = "English (US)",
series = "IEEE International Ultrasonics Symposium, IUS",
publisher = "IEEE Computer Society",
pages = "2049--2051",
booktitle = "2019 IEEE International Ultrasonics Symposium, IUS 2019",
}