4D imaging of embryonic chick hearts by streak-mode Fourier domain optical coherence tomography

Rui Wang, Julie X. Yun, Richard Goodwin, Roger Markwald, Thomas K. Borg, Raymond B. Runyan, Bruce Gao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


Recently, we developed the streak-mode Fourier domain optical coherence tomography (OCT) technique in which an area-scan camera is used in a streak-mode to record the OCT spectrum. Here we report the application of this technique to in ovo imaging HH18 embryonic chick hearts with an ultrahigh speed of 1,016,000 axial scans per second. The highscan rate enables the acquisition of high temporal resolution 2D datasets (1,000 frames per second or 1 ms between frames) and 3D datasets (10 volumes per second), without use of prospective or retrospective gating technique. This marks the first time that the embryonic animal heart has been 4D imaged using a megahertz OCT.

Original languageEnglish (US)
Title of host publicationPhotonic Therapeutics and Diagnostics VIII
StatePublished - 2012
EventPhotonic Therapeutics and Diagnostics VIII - San Francisco, CA, United States
Duration: Jan 21 2012Jan 24 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherPhotonic Therapeutics and Diagnostics VIII
Country/TerritoryUnited States
CitySan Francisco, CA


  • Fourier domain
  • Heart development
  • Optical coherence tomography
  • Streak mode

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Biomaterials


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