TY - GEN
T1 - 4D Cardiac Activation Wave Mapping in In Vivo Swine Model using Acoustoelectric Imaging
AU - Alvarez, Alexander
AU - Wilhite, Cameron
AU - Preston, Chet
AU - Trujillo, Teo
AU - McArthur, Alice
AU - Mustacich, Debbie
AU - Witte, Russell S.
N1 - Publisher Copyright:
© 2019 IEEE.
PY - 2019/10
Y1 - 2019/10
N2 - Though atrial fibrillation (AF) is a growing public health problem, electrical characterization of the disease with electrocardiography (ECG) is inadequate due to poor spatial resolution. The goal of this study was to investigate propagation of the cardiac activation wave in a healthy swine model using acoustoelectric cardiac imaging (ACI), a noninvasive mapping technology that combines ultrasound with electrical recording to overcome limitations with standard ECG. Real-time 4D ACI with a custom 2D 0.6 MHz matrix US array demonstrated conduction velocities of 2.21 m/s, validated with standard epicardial recording. ACI FWHM at a single timepoint, a measure related to the resolution of ACI in imaging the volume of activation at peak ECG signal, was 7.31 mm, 7.63 mm, and 6.23 mm in the depth, lateral, and elevational directions, respectively. SNR of ACI was 21dB at peak activation. ACI signals tracked through a 4D volume demonstrated appropriate propagation of the signal from base to apex and from endocardium to epicardium. This study demonstrated the potential for this technology to noninvasively map arrhythmias, such as AF, at high resolution.
AB - Though atrial fibrillation (AF) is a growing public health problem, electrical characterization of the disease with electrocardiography (ECG) is inadequate due to poor spatial resolution. The goal of this study was to investigate propagation of the cardiac activation wave in a healthy swine model using acoustoelectric cardiac imaging (ACI), a noninvasive mapping technology that combines ultrasound with electrical recording to overcome limitations with standard ECG. Real-time 4D ACI with a custom 2D 0.6 MHz matrix US array demonstrated conduction velocities of 2.21 m/s, validated with standard epicardial recording. ACI FWHM at a single timepoint, a measure related to the resolution of ACI in imaging the volume of activation at peak ECG signal, was 7.31 mm, 7.63 mm, and 6.23 mm in the depth, lateral, and elevational directions, respectively. SNR of ACI was 21dB at peak activation. ACI signals tracked through a 4D volume demonstrated appropriate propagation of the signal from base to apex and from endocardium to epicardium. This study demonstrated the potential for this technology to noninvasively map arrhythmias, such as AF, at high resolution.
KW - arrhythmia
KW - atrial fibrillation
KW - cardiac mapping
KW - echocardiography
KW - electrocardiography
UR - http://www.scopus.com/inward/record.url?scp=85077634970&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85077634970&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2019.8926147
DO - 10.1109/ULTSYM.2019.8926147
M3 - Conference contribution
AN - SCOPUS:85077634970
T3 - IEEE International Ultrasonics Symposium, IUS
SP - 1414
EP - 1417
BT - 2019 IEEE International Ultrasonics Symposium, IUS 2019
PB - IEEE Computer Society
T2 - 2019 IEEE International Ultrasonics Symposium, IUS 2019
Y2 - 6 October 2019 through 9 October 2019
ER -