46th Annual Meeting of the Society for Gynecologic Investigation, Atlanta, Georgia, U.S.A., March 10-13, 1999: The role of amniotic fluid interleukin-6, and cell adhesion molecules, intercellular adhesion molecule-1 and leukocyte adhesion molecule-1, in intra-amniotic infection

Chaur Dong Hsu, Kristen Aversa, Erika Meaddough

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

PROBLEM: To determine amniotic fluid concentrations and correlations of interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), and leukocyte adhesion molecule-1 (LAM-1) in patients with and without intra-amniotic infection. METHOD OF STUDY: Fourteen specimens with intra-amniotic infection and 45 without intra-amniotic infection were studied. Intra-amniotic infection was defined as the presence of a positive amniotic fluid culture. Amniotic fluid IL-6, ICAM-1, and LAM-1 levels were determined by an enzyme-linked immunoassay, and normalized by amniotic fluid creatinine levels. RESULTS: Amniotic fluid concentrations of IL-6 and LAM-1 were significantly higher in patients with than without intra-amniotic infection. However, amniotic fluid ICAM-1 concentrations were not significantly different between two groups. Amniotic fluid IL-6, LAM-1, and ICAM-1 were positively correlated. CONCLUSIONS: Our data indicate that amniotic fluid IL-6 is significantly associated with an increased adhesion molecule expression in intra-amniotic infection. However, LAM-1 plays a more important role than ICAM-1 in intra-amniotic infection.

Original languageEnglish (US)
Pages (from-to)251-254
Number of pages4
JournalAmerican Journal of Reproductive Immunology
Volume43
Issue number5
StatePublished - May 2000
Externally publishedYes

Keywords

  • Amniotic fluid
  • Intercellular adhesion molecule
  • Interleukin-6
  • Intra-amniotic infection
  • Leukocyte adhesion molecule-1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

Fingerprint

Dive into the research topics of '46th Annual Meeting of the Society for Gynecologic Investigation, Atlanta, Georgia, U.S.A., March 10-13, 1999: The role of amniotic fluid interleukin-6, and cell adhesion molecules, intercellular adhesion molecule-1 and leukocyte adhesion molecule-1, in intra-amniotic infection'. Together they form a unique fingerprint.

Cite this