4-Oxo-(E)-2-hexenal produced by Heteroptera induces permanent locomotive impairment in crickets that correlates with free thiol depletion

Koji Noge; Judith X. Becerra

doi:10.1016/j.fob.2015.04.004

4-Oxo-(E)-2-hexenal produced by Heteroptera induces permanent locomotive impairment in crickets that correlates with free thiol depletion

Koji Noge, Judith X. Becerra

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4 Scopus citations

Abstract

Heteropterans produce 2-alkenals and 4-keto-2-alkenals that function as defense substances or pheromones. However, in spite of advances in heteropteran chemistry, it is still unclear how these compounds affect insect physiology. We found that exposure to 4-oxo-(. E)-2-hexenal (OHE) induced permanent paralysis and death in crickets, an experimental model. The depletion of free thiols in leg tissues of OHE-treated crickets and the in vitro adduct formation of OHE with a thiol compound suggest that covalent binding of OHE to biologically active thiols is a potential cause affecting crickets' locomotion.

Original language	English (US)
Pages (from-to)	319-324
Number of pages	6
Journal	FEBS Open Bio
Volume	5
DOIs	https://doi.org/10.1016/j.fob.2015.04.004
State	Published - Jan 1 2015

Keywords

2-Alkenals
4-oxo-(E)-2-hexenal
Anti-predatory defense
Insect locomotion
Lipid-peroxidation product
Paralysis

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.fob.2015.04.004

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title = "4-Oxo-(E)-2-hexenal produced by Heteroptera induces permanent locomotive impairment in crickets that correlates with free thiol depletion",

abstract = "Heteropterans produce 2-alkenals and 4-keto-2-alkenals that function as defense substances or pheromones. However, in spite of advances in heteropteran chemistry, it is still unclear how these compounds affect insect physiology. We found that exposure to 4-oxo-(. E)-2-hexenal (OHE) induced permanent paralysis and death in crickets, an experimental model. The depletion of free thiols in leg tissues of OHE-treated crickets and the in vitro adduct formation of OHE with a thiol compound suggest that covalent binding of OHE to biologically active thiols is a potential cause affecting crickets' locomotion.",

keywords = "2-Alkenals, 4-oxo-(E)-2-hexenal, Anti-predatory defense, Insect locomotion, Lipid-peroxidation product, Paralysis",

author = "Koji Noge and Becerra, {Judith X.}",

note = "Funding Information: We thank Neil Jacobsen and Guangxin Lin (University of Arizona) for acquiring the NMR spectra. We are also grateful to Xianchun Li (University of Arizona) and all of the members in his lab for their considerable help. We thank Naoki Mori (Kyoto University) for providing the information about the reaction of 1-BuSH. This work was supported by a Grant from the BIO5 Institute of the University of Arizona to JXB. KN designed and performed the experiments, KN and JXB analyzed the data and wrote the paper. Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2015",

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doi = "10.1016/j.fob.2015.04.004",

language = "English (US)",

volume = "5",

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AU - Noge, Koji

AU - Becerra, Judith X.

N1 - Funding Information: We thank Neil Jacobsen and Guangxin Lin (University of Arizona) for acquiring the NMR spectra. We are also grateful to Xianchun Li (University of Arizona) and all of the members in his lab for their considerable help. We thank Naoki Mori (Kyoto University) for providing the information about the reaction of 1-BuSH. This work was supported by a Grant from the BIO5 Institute of the University of Arizona to JXB. KN designed and performed the experiments, KN and JXB analyzed the data and wrote the paper. Publisher Copyright: © 2015 The Authors.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Heteropterans produce 2-alkenals and 4-keto-2-alkenals that function as defense substances or pheromones. However, in spite of advances in heteropteran chemistry, it is still unclear how these compounds affect insect physiology. We found that exposure to 4-oxo-(. E)-2-hexenal (OHE) induced permanent paralysis and death in crickets, an experimental model. The depletion of free thiols in leg tissues of OHE-treated crickets and the in vitro adduct formation of OHE with a thiol compound suggest that covalent binding of OHE to biologically active thiols is a potential cause affecting crickets' locomotion.

AB - Heteropterans produce 2-alkenals and 4-keto-2-alkenals that function as defense substances or pheromones. However, in spite of advances in heteropteran chemistry, it is still unclear how these compounds affect insect physiology. We found that exposure to 4-oxo-(. E)-2-hexenal (OHE) induced permanent paralysis and death in crickets, an experimental model. The depletion of free thiols in leg tissues of OHE-treated crickets and the in vitro adduct formation of OHE with a thiol compound suggest that covalent binding of OHE to biologically active thiols is a potential cause affecting crickets' locomotion.

KW - 2-Alkenals

KW - 4-oxo-(E)-2-hexenal

KW - Anti-predatory defense

KW - Insect locomotion

KW - Lipid-peroxidation product

KW - Paralysis

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JO - FEBS Open Bio

JF - FEBS Open Bio

ER -

4-Oxo-(E)-2-hexenal produced by Heteroptera induces permanent locomotive impairment in crickets that correlates with free thiol depletion

Abstract

Keywords

ASJC Scopus subject areas

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