4-Oxo-(E)-2-hexenal produced by Heteroptera induces permanent locomotive impairment in crickets that correlates with free thiol depletion

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3 Scopus citations

Abstract

Heteropterans produce 2-alkenals and 4-keto-2-alkenals that function as defense substances or pheromones. However, in spite of advances in heteropteran chemistry, it is still unclear how these compounds affect insect physiology. We found that exposure to 4-oxo-(. E)-2-hexenal (OHE) induced permanent paralysis and death in crickets, an experimental model. The depletion of free thiols in leg tissues of OHE-treated crickets and the in vitro adduct formation of OHE with a thiol compound suggest that covalent binding of OHE to biologically active thiols is a potential cause affecting crickets' locomotion.

Original languageEnglish (US)
Pages (from-to)319-324
Number of pages6
JournalFEBS Open Bio
Volume5
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • 2-Alkenals
  • 4-oxo-(E)-2-hexenal
  • Anti-predatory defense
  • Insect locomotion
  • Lipid-peroxidation product
  • Paralysis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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