4-leucine-oxytocin: Natriuretic, diuretic, and antivasopressin polypeptide

W. Y. Chan; Victor J. Hruby; George Flouret; Vincent Du Vigneaud

doi:10.1126/science.161.3838.280

4-leucine-oxytocin: Natriuretic, diuretic, and antivasopressin polypeptide

W. Y. Chan, Victor J. Hruby, George Flouret, Vincent Du Vigneaud

Research output: Contribution to journal › Article › peer-review

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Abstract

During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucineoxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to free-water clearance.

Original language	English (US)
Pages (from-to)	280-281
Number of pages	2
Journal	Science
Volume	161
Issue number	3838
DOIs	https://doi.org/10.1126/science.161.3838.280
State	Published - 1968
Externally published	Yes

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title = "4-leucine-oxytocin: Natriuretic, diuretic, and antivasopressin polypeptide",

abstract = "During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucineoxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to free-water clearance.",

author = "Chan, {W. Y.} and Hruby, {Victor J.} and George Flouret and {Du Vigneaud}, Vincent",

year = "1968",

doi = "10.1126/science.161.3838.280",

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T2 - Natriuretic, diuretic, and antivasopressin polypeptide

AU - Chan, W. Y.

AU - Hruby, Victor J.

AU - Flouret, George

AU - Du Vigneaud, Vincent

PY - 1968

Y1 - 1968

N2 - During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucineoxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to free-water clearance.

AB - During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucineoxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to free-water clearance.

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ER -

4-leucine-oxytocin: Natriuretic, diuretic, and antivasopressin polypeptide

Abstract

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