3D silicon neural probe with integrated optical fibers for optogenetic modulation

Eric G.R. Kim, Hongen Tu, Hao Luo, Bin Liu, Shaowen Bao, Jinsheng Zhang, Yong Xu

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Optogenetics is a powerful modality for neural modulation that can be useful for a wide array of biomedical studies. Penetrating microelectrode arrays provide a means of recording neural signals with high spatial resolution. It is highly desirable to integrate optics with neural probes to allow for functional study of neural tissue by optogenetics. In this paper, we report the development of a novel 3D neural probe coupled simply and robustly to optical fibers using a hollow parylene tube structure. The device shanks are hollow tubes with rigid silicon tips, allowing the insertion and encasement of optical fibers within the shanks. The position of the fiber tip can be precisely controlled relative to the electrodes on the shank by inherent design features. Preliminary in vivo rat studies indicate that these devices are capable of optogenetic modulation simultaneously with 3D neural signal recording.

Original languageEnglish (US)
Pages (from-to)2939-2949
Number of pages11
JournalLab on a Chip
Volume15
Issue number14
DOIs
StatePublished - Jul 21 2015

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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