TY - GEN
T1 - 3D Position Estimation for the AdaptiSPECT-C Modular Gamma-Ray Cameras
AU - Doty, Kimberly J.
AU - Kupinski, Matthew A.
AU - Richards, R. Garrett
AU - Ruiz-Gonzalez, Maria
AU - King, Michael A.
AU - Kuo, Phillip H.
AU - Furenlid, Lars R.
N1 - Publisher Copyright:
© 2021 IEEE.
PY - 2021
Y1 - 2021
N2 - We are developing a single-photon emission computed tomography (SPECT) system for human brain imaging called AdaptiSPECT-C. It consists of a stationary hemisphere of 24 cameras. The system will be used for pharmacokinetic studies and drug discovery for neurodegenerative diseases. Our final camera design uses a novel light-sensor configuration that combines silicon photomultipliers (SiPMs) and photomultiplier tubes (PMTs) to improve the spatial resolution at the corners and edges of the modular camera. In this work, we have used a Monte Carlo simulation to create 3D mean detector response functions (MDRFs). We used the 3D MDRFS to estimate the 3D intrinsic spatial resolution of the cameras for our system by using the Cramer-Rao Lower Bound derived from Fisher-Information Matrices. We report on the effects of scintillation crystal edge treatments, the light yield of the crystal, and the quantum efficiency of the sensors on the intrinsic 3D spatial resolution.
AB - We are developing a single-photon emission computed tomography (SPECT) system for human brain imaging called AdaptiSPECT-C. It consists of a stationary hemisphere of 24 cameras. The system will be used for pharmacokinetic studies and drug discovery for neurodegenerative diseases. Our final camera design uses a novel light-sensor configuration that combines silicon photomultipliers (SiPMs) and photomultiplier tubes (PMTs) to improve the spatial resolution at the corners and edges of the modular camera. In this work, we have used a Monte Carlo simulation to create 3D mean detector response functions (MDRFs). We used the 3D MDRFS to estimate the 3D intrinsic spatial resolution of the cameras for our system by using the Cramer-Rao Lower Bound derived from Fisher-Information Matrices. We report on the effects of scintillation crystal edge treatments, the light yield of the crystal, and the quantum efficiency of the sensors on the intrinsic 3D spatial resolution.
KW - 3D spatial resolution
KW - Monte Carlo simulation
KW - depth-of-interaction
KW - gamma camera design
KW - human brain imager
KW - molecular imaging
KW - parallax error
KW - single photon emission computed tomography
UR - http://www.scopus.com/inward/record.url?scp=85139106967&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85139106967&partnerID=8YFLogxK
U2 - 10.1109/NSS/MIC44867.2021.9875617
DO - 10.1109/NSS/MIC44867.2021.9875617
M3 - Conference contribution
AN - SCOPUS:85139106967
T3 - 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022
BT - 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022
A2 - Tomita, Hideki
A2 - Nakamura, Tatsuya
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2021
Y2 - 16 October 2021 through 23 October 2021
ER -