3D Position Estimation for the AdaptiSPECT-C Modular Gamma-Ray Cameras

Kimberly J. Doty, Matthew A. Kupinski, R. Garrett Richards, Maria Ruiz-Gonzalez, Michael A. King, Phillip H. Kuo, Lars R. Furenlid

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

We are developing a single-photon emission computed tomography (SPECT) system for human brain imaging called AdaptiSPECT-C. It consists of a stationary hemisphere of 24 cameras. The system will be used for pharmacokinetic studies and drug discovery for neurodegenerative diseases. Our final camera design uses a novel light-sensor configuration that combines silicon photomultipliers (SiPMs) and photomultiplier tubes (PMTs) to improve the spatial resolution at the corners and edges of the modular camera. In this work, we have used a Monte Carlo simulation to create 3D mean detector response functions (MDRFs). We used the 3D MDRFS to estimate the 3D intrinsic spatial resolution of the cameras for our system by using the Cramer-Rao Lower Bound derived from Fisher-Information Matrices. We report on the effects of scintillation crystal edge treatments, the light yield of the crystal, and the quantum efficiency of the sensors on the intrinsic 3D spatial resolution.

Original languageEnglish (US)
Title of host publication2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022
EditorsHideki Tomita, Tatsuya Nakamura
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781665421133
DOIs
StatePublished - 2021
Event2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2021 - Virtual, Yokohama, Japan
Duration: Oct 16 2021Oct 23 2021

Publication series

Name2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022

Conference

Conference2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2021
Country/TerritoryJapan
CityVirtual, Yokohama
Period10/16/2110/23/21

Keywords

  • 3D spatial resolution
  • Monte Carlo simulation
  • depth-of-interaction
  • gamma camera design
  • human brain imager
  • molecular imaging
  • parallax error
  • single photon emission computed tomography

ASJC Scopus subject areas

  • Nuclear Energy and Engineering
  • Health Informatics
  • Radiology Nuclear Medicine and imaging
  • Nuclear and High Energy Physics

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