3-(glutathion-S-yl)acetaminophen: A biliary metabolite of acetaminophen

J. A. Hinson; T. J. Monks; M. Hong; R. J. Highet; L. R. Pohl

3-(glutathion-S-yl)acetaminophen: A biliary metabolite of acetaminophen

J. A. Hinson
, T. J. Monks
, M. Hong
, R. J. Highet
, L. R. Pohl

Research output: Contribution to journal › Article › peer-review

Abstract

A glutathione conjugate of acetaminophen was isolated by preparative high-performance liquid chromatography from the bile of rats that had been given acetaminophen (500 mg/kg ip). Its ¹³C- and ¹H-NMR spectra revealed that the conjugate was 3-(glutathion-S-yl)acetaminophen.

Original language	English (US)
Pages (from-to)	47-50
Number of pages	4
Journal	Drug Metabolism and Disposition
Volume	10
Issue number	1
State	Published - 1982
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Cite this

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title = "3-(glutathion-S-yl)acetaminophen: A biliary metabolite of acetaminophen",

abstract = "A glutathione conjugate of acetaminophen was isolated by preparative high-performance liquid chromatography from the bile of rats that had been given acetaminophen (500 mg/kg ip). Its 13C- and 1H-NMR spectra revealed that the conjugate was 3-(glutathion-S-yl)acetaminophen.",

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year = "1982",

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journal = "Drug Metabolism and Disposition",

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T1 - 3-(glutathion-S-yl)acetaminophen

T2 - A biliary metabolite of acetaminophen

AU - Hinson, J. A.

AU - Monks, T. J.

AU - Hong, M.

AU - Highet, R. J.

AU - Pohl, L. R.

PY - 1982

Y1 - 1982

N2 - A glutathione conjugate of acetaminophen was isolated by preparative high-performance liquid chromatography from the bile of rats that had been given acetaminophen (500 mg/kg ip). Its 13C- and 1H-NMR spectra revealed that the conjugate was 3-(glutathion-S-yl)acetaminophen.

AB - A glutathione conjugate of acetaminophen was isolated by preparative high-performance liquid chromatography from the bile of rats that had been given acetaminophen (500 mg/kg ip). Its 13C- and 1H-NMR spectra revealed that the conjugate was 3-(glutathion-S-yl)acetaminophen.

UR - https://www.scopus.com/pages/publications/0020076955

UR - https://www.scopus.com/pages/publications/0020076955#tab=citedBy

M3 - Article

C2 - 6124382

AN - SCOPUS:0020076955

SN - 0090-9556

VL - 10

SP - 47

EP - 50

JO - Drug Metabolism and Disposition

JF - Drug Metabolism and Disposition

IS - 1

ER -

3-(glutathion-S-yl)acetaminophen: A biliary metabolite of acetaminophen

Abstract

ASJC Scopus subject areas

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