3-(glutathion-S-yl)acetaminophen: A biliary metabolite of acetaminophen

J. A. Hinson; T. J. Monks; M. Hong; R. J. Highet; L. R. Pohl

3-(glutathion-S-yl)acetaminophen: A biliary metabolite of acetaminophen

J. A. Hinson, T. J. Monks, M. Hong, R. J. Highet, L. R. Pohl

Research output: Contribution to journal › Article › peer-review

Abstract

A glutathione conjugate of acetaminophen was isolated by preparative high-performance liquid chromatography from the bile of rats that had been given acetaminophen (500 mg/kg ip). Its ¹³C- and ¹H-NMR spectra revealed that the conjugate was 3-(glutathion-S-yl)acetaminophen.

Original language	English (US)
Pages (from-to)	47-50
Number of pages	4
Journal	Drug Metabolism and Disposition
Volume	10
Issue number	1
State	Published - 1982
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Cite this

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title = "3-(glutathion-S-yl)acetaminophen: A biliary metabolite of acetaminophen",

abstract = "A glutathione conjugate of acetaminophen was isolated by preparative high-performance liquid chromatography from the bile of rats that had been given acetaminophen (500 mg/kg ip). Its 13C- and 1H-NMR spectra revealed that the conjugate was 3-(glutathion-S-yl)acetaminophen.",

author = "Hinson, {J. A.} and Monks, {T. J.} and M. Hong and Highet, {R. J.} and Pohl, {L. R.}",

year = "1982",

language = "English (US)",

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AU - Hinson, J. A.

AU - Monks, T. J.

AU - Hong, M.

AU - Highet, R. J.

AU - Pohl, L. R.

PY - 1982

Y1 - 1982

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AB - A glutathione conjugate of acetaminophen was isolated by preparative high-performance liquid chromatography from the bile of rats that had been given acetaminophen (500 mg/kg ip). Its 13C- and 1H-NMR spectra revealed that the conjugate was 3-(glutathion-S-yl)acetaminophen.

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AN - SCOPUS:0020076955

SN - 0090-9556

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ER -

3-(glutathion-S-yl)acetaminophen: A biliary metabolite of acetaminophen

Abstract

ASJC Scopus subject areas

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