3-(glutathion-S-yl)acetaminophen: A biliary metabolite of acetaminophen

J. A. Hinson; T. J. Monks; M. Hong; R. J. Highet; L. R. Pohl

3-(glutathion-S-yl)acetaminophen: A biliary metabolite of acetaminophen

J. A. Hinson, T. J. Monks, M. Hong, R. J. Highet, L. R. Pohl

Research output: Contribution to journal › Article › peer-review

Abstract

A glutathione conjugate of acetaminophen was isolated by preparative high-performance liquid chromatography from the bile of rats that had been given acetaminophen (500 mg/kg ip). Its ¹³C- and ¹H-NMR spectra revealed that the conjugate was 3-(glutathion-S-yl)acetaminophen.

Original language	English (US)
Pages (from-to)	47-50
Number of pages	4
Journal	Drug Metabolism and Disposition
Volume	10
Issue number	1
State	Published - 1982
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Cite this

@article{7fe8d63679474f6e8ca05a67ee37c2ed,

title = "3-(glutathion-S-yl)acetaminophen: A biliary metabolite of acetaminophen",

abstract = "A glutathione conjugate of acetaminophen was isolated by preparative high-performance liquid chromatography from the bile of rats that had been given acetaminophen (500 mg/kg ip). Its 13C- and 1H-NMR spectra revealed that the conjugate was 3-(glutathion-S-yl)acetaminophen.",

author = "Hinson, {J. A.} and Monks, {T. J.} and M. Hong and Highet, {R. J.} and Pohl, {L. R.}",

year = "1982",

language = "English (US)",

volume = "10",

pages = "47--50",

journal = "Drug Metabolism and Disposition",

issn = "0090-9556",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - 3-(glutathion-S-yl)acetaminophen

T2 - A biliary metabolite of acetaminophen

AU - Hinson, J. A.

AU - Monks, T. J.

AU - Hong, M.

AU - Highet, R. J.

AU - Pohl, L. R.

PY - 1982

Y1 - 1982

N2 - A glutathione conjugate of acetaminophen was isolated by preparative high-performance liquid chromatography from the bile of rats that had been given acetaminophen (500 mg/kg ip). Its 13C- and 1H-NMR spectra revealed that the conjugate was 3-(glutathion-S-yl)acetaminophen.

AB - A glutathione conjugate of acetaminophen was isolated by preparative high-performance liquid chromatography from the bile of rats that had been given acetaminophen (500 mg/kg ip). Its 13C- and 1H-NMR spectra revealed that the conjugate was 3-(glutathion-S-yl)acetaminophen.

UR - http://www.scopus.com/inward/record.url?scp=0020076955&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020076955&partnerID=8YFLogxK

M3 - Article

C2 - 6124382

AN - SCOPUS:0020076955

SN - 0090-9556

VL - 10

SP - 47

EP - 50

JO - Drug Metabolism and Disposition

JF - Drug Metabolism and Disposition

IS - 1

ER -

3-(glutathion-S-yl)acetaminophen: A biliary metabolite of acetaminophen

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this