[2,4-Diisoleucine]-oxytocin. An analog of oxytocin with natriuretic and diuretic activities

Victor J. Hruby, Vincent Du Vigneaud, W. Y. Chan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


[2,4-Diisoleucine]-oxytocin has been synthesized from the requisite protected nonapeptide intermediate which was prepared by the stepwise p-nitrophenyl ester method. In this analog of oxytocin, isoleucine residues replace the tyrosine and glutamine residues at the 2 and 4 positions of the hormone, and thus the isoleucine residue occurs successively at positions 2, 3, and 4. This compound possesses a very low level of avian vasodepressor, oxytocic, and pressor activities, and no antidiuretic activity. However, [2,4-diisoleucine]-oxytocin has a pronounced natriuretic activity and a mild diuretic effect.

Original languageEnglish (US)
Pages (from-to)185-187
Number of pages3
JournalJournal of Medicinal Chemistry
Issue number2
StatePublished - 1970
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


Dive into the research topics of '[2,4-Diisoleucine]-oxytocin. An analog of oxytocin with natriuretic and diuretic activities'. Together they form a unique fingerprint.

Cite this