Abstract
Synthetic studies toward the gibberellin family of natural products are reported. An oxidative dearomatization/Diels-Alder cascade assembles the carbon skeleton as a [2.2.2]-bicycle, which is then transformed to the [3.2.1]-bicyclic gibberellin core via a novel Lewis acid catalyzed rearrangement. Strategic synthetic handles allow for late-stage modification of the gibberellin skeleton and provides efficient access to this important family of natural compounds.
Original language | English (US) |
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Pages (from-to) | 2993-2996 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 20 |
Issue number | 10 |
DOIs | |
State | Published - May 18 2018 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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CCDC 1821698: Experimental Crystal Structure Determination
Smith, B. R. (Creator) & Njardarson, J. T. (Creator), Cambridge Crystallographic Data Centre, 2018
DOI: 10.5517/ccdc.csd.cc1z4mg6, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1z4mg6&sid=DataCite
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