14-3-3 proteins: Do they have a role in human cancer?

Jesse D. Martinez

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The 14-3-3 proteins are a family of adaptors that have recently gained a lot of attention due to the discovery that they may play an important role in human tumorigenesis. Examination of human tumors shows that expression of these proteins is increased in some tumors and decreased in others. Since biochemical studies suggest that 14-3-3 proteins regulate multiple pathways that are also disrupted during tumorigenesis, it is unclear how they actually contribute to tumor development.

Original languageEnglish (US)
Pages (from-to)631-633
Number of pages3
JournalFuture Oncology
Issue number5
StatePublished - Oct 2005


  • 14-3-3
  • cancer
  • methylation
  • oncogene
  • p53
  • raf
  • tumor suppressor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of '14-3-3 proteins: Do they have a role in human cancer?'. Together they form a unique fingerprint.

Cite this