14-3-3 proteins: Do they have a role in human cancer?

Jesse D. Martinez

doi:10.2217/14796694.1.5.631

14-3-3 proteins: Do they have a role in human cancer?

Jesse D. Martinez

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The 14-3-3 proteins are a family of adaptors that have recently gained a lot of attention due to the discovery that they may play an important role in human tumorigenesis. Examination of human tumors shows that expression of these proteins is increased in some tumors and decreased in others. Since biochemical studies suggest that 14-3-3 proteins regulate multiple pathways that are also disrupted during tumorigenesis, it is unclear how they actually contribute to tumor development.

Original language	English (US)
Pages (from-to)	631-633
Number of pages	3
Journal	Future Oncology
Volume	1
Issue number	5
DOIs	https://doi.org/10.2217/14796694.1.5.631
State	Published - Oct 2005
Externally published	Yes

Keywords

14-3-3
cancer
methylation
oncogene
p53
raf
tumor suppressor

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.2217/14796694.1.5.631

Cite this

@article{c81b34c99ca546f38fd0fe26f66f5486,

title = "14-3-3 proteins: Do they have a role in human cancer?",

abstract = "The 14-3-3 proteins are a family of adaptors that have recently gained a lot of attention due to the discovery that they may play an important role in human tumorigenesis. Examination of human tumors shows that expression of these proteins is increased in some tumors and decreased in others. Since biochemical studies suggest that 14-3-3 proteins regulate multiple pathways that are also disrupted during tumorigenesis, it is unclear how they actually contribute to tumor development.",

keywords = "14-3-3, cancer, methylation, oncogene, p53, raf, tumor suppressor",

author = "Martinez, {Jesse D.}",

year = "2005",

month = oct,

doi = "10.2217/14796694.1.5.631",

language = "English (US)",

volume = "1",

pages = "631--633",

journal = "Future Oncology",

issn = "1479-6694",

publisher = "Taylor and Francis Ltd.",

number = "5",

}

TY - JOUR

T1 - 14-3-3 proteins

T2 - Do they have a role in human cancer?

AU - Martinez, Jesse D.

PY - 2005/10

Y1 - 2005/10

N2 - The 14-3-3 proteins are a family of adaptors that have recently gained a lot of attention due to the discovery that they may play an important role in human tumorigenesis. Examination of human tumors shows that expression of these proteins is increased in some tumors and decreased in others. Since biochemical studies suggest that 14-3-3 proteins regulate multiple pathways that are also disrupted during tumorigenesis, it is unclear how they actually contribute to tumor development.

AB - The 14-3-3 proteins are a family of adaptors that have recently gained a lot of attention due to the discovery that they may play an important role in human tumorigenesis. Examination of human tumors shows that expression of these proteins is increased in some tumors and decreased in others. Since biochemical studies suggest that 14-3-3 proteins regulate multiple pathways that are also disrupted during tumorigenesis, it is unclear how they actually contribute to tumor development.

KW - 14-3-3

KW - cancer

KW - methylation

KW - oncogene

KW - p53

KW - raf

KW - tumor suppressor

UR - http://www.scopus.com/inward/record.url?scp=36049050646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36049050646&partnerID=8YFLogxK

U2 - 10.2217/14796694.1.5.631

DO - 10.2217/14796694.1.5.631

M3 - Article

C2 - 16556040

AN - SCOPUS:36049050646

SN - 1479-6694

VL - 1

SP - 631

EP - 633

JO - Future Oncology

JF - Future Oncology

IS - 5

ER -

14-3-3 proteins: Do they have a role in human cancer?

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this