13α–Hydroxylucilactaene and Other Metabolites of an Endophytic Strain of Fusarium acuminatum

Bharat P. Bashyal, Stanley H. Faeth, A. A.Leslie Gunatilaka

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A liquid fermentation culture of Fusarium acuminatum, endophytic in the root of Larrea tritentata, afforded a new furanopyrrolidone, 13α–hydroxylucilactaene (1), together with four known metabolites, NG–391 (2), NG–393 (3), enniatin A (4), and enniatin B (5). The structure and relative stereochemistry of 1 was established by extensive NMR spectral analysis and the known compounds 2 – 5 were identified by comparison of their spectroscopic data with those reported in the literature. The cytotoxicity of all compounds was evaluated in a panel of five human cancer cell lines [NCI–H460 (non-small cell lung), MCF–7 (breast), SF–268 (CNS glioma), MIA Pa Ca–2 (pancreatic carcinoma), PC-3M (metastatic prostate cancer)] and normal human fibroblast (WI–38) cells, and only enniatins A (4) and B (5) were shown to have significant cytotoxic activity.

Original languageEnglish (US)
JournalNatural Product Communications
Volume2
Issue number5
DOIs
StatePublished - May 2007

Keywords

  • 13α–hydroxylucilactaene
  • anticancer agents
  • bioactivity–guided fractionation
  • Fusarium acuminatum

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

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