TY - JOUR
T1 - 13α–Hydroxylucilactaene and Other Metabolites of an Endophytic Strain of Fusarium acuminatum
AU - Bashyal, Bharat P.
AU - Faeth, Stanley H.
AU - Gunatilaka, A. A.Leslie
N1 - Publisher Copyright:
© 2007 SAGE Publications Inc.
PY - 2007/5
Y1 - 2007/5
N2 - A liquid fermentation culture of Fusarium acuminatum, endophytic in the root of Larrea tritentata, afforded a new furanopyrrolidone, 13α–hydroxylucilactaene (1), together with four known metabolites, NG–391 (2), NG–393 (3), enniatin A (4), and enniatin B (5). The structure and relative stereochemistry of 1 was established by extensive NMR spectral analysis and the known compounds 2 – 5 were identified by comparison of their spectroscopic data with those reported in the literature. The cytotoxicity of all compounds was evaluated in a panel of five human cancer cell lines [NCI–H460 (non-small cell lung), MCF–7 (breast), SF–268 (CNS glioma), MIA Pa Ca–2 (pancreatic carcinoma), PC-3M (metastatic prostate cancer)] and normal human fibroblast (WI–38) cells, and only enniatins A (4) and B (5) were shown to have significant cytotoxic activity.
AB - A liquid fermentation culture of Fusarium acuminatum, endophytic in the root of Larrea tritentata, afforded a new furanopyrrolidone, 13α–hydroxylucilactaene (1), together with four known metabolites, NG–391 (2), NG–393 (3), enniatin A (4), and enniatin B (5). The structure and relative stereochemistry of 1 was established by extensive NMR spectral analysis and the known compounds 2 – 5 were identified by comparison of their spectroscopic data with those reported in the literature. The cytotoxicity of all compounds was evaluated in a panel of five human cancer cell lines [NCI–H460 (non-small cell lung), MCF–7 (breast), SF–268 (CNS glioma), MIA Pa Ca–2 (pancreatic carcinoma), PC-3M (metastatic prostate cancer)] and normal human fibroblast (WI–38) cells, and only enniatins A (4) and B (5) were shown to have significant cytotoxic activity.
KW - 13α–hydroxylucilactaene
KW - anticancer agents
KW - bioactivity–guided fractionation
KW - Fusarium acuminatum
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U2 - 10.1177/1934578X0700200507
DO - 10.1177/1934578X0700200507
M3 - Article
AN - SCOPUS:85127057189
VL - 2
JO - Natural Product Communications
JF - Natural Product Communications
SN - 1934-578X
IS - 5
ER -