1, 2-Asymmetric cis induction and its application to the asymmetric synthesis of precursors of β-branched unusual amino acids

Guigen Li; Dinesh Patel; Victor J. Hruby

doi:10.1016/0040-4039(94)85204-9

1, 2-Asymmetric cis induction and its application to the asymmetric synthesis of precursors of β-branched unusual amino acids

Guigen Li
, Dinesh Patel
, Victor J. Hruby

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A new method for the asymmetric synthesis of key intermediates of unusual amino acids has been established by utilizing β-carbon chirality for asymmetric induction in allylic-strained boron enolates.

Original language	English (US)
Pages (from-to)	2301-2304
Number of pages	4
Journal	Tetrahedron Letters
Volume	35
Issue number	15
DOIs	https://doi.org/10.1016/0040-4039(94)85204-9
State	Published - Apr 11 1994
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/0040-4039(94)85204-9

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title = "1, 2-Asymmetric cis induction and its application to the asymmetric synthesis of precursors of β-branched unusual amino acids",

abstract = "A new method for the asymmetric synthesis of key intermediates of unusual amino acids has been established by utilizing β-carbon chirality for asymmetric induction in allylic-strained boron enolates.",

author = "Guigen Li and Dinesh Patel and Hruby, \{Victor J.\}",

note = "Funding Information: Acknowledgment This work has been supportedb y U. S. Public Service Grants, DK 36289 and CA 57723, and NIDA Grants DA 06284 and DA 04248. and SRSF GraduateS cholarship (University of Arizona, GLi172317).We would like to thank Dr. Michael Bruck for the X-ray structure analysis, Dr. Robin Polt for the helpful discussions.a nd Dr. B.-S. Lou for her assistance.",

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doi = "10.1016/0040-4039(94)85204-9",

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T1 - 1, 2-Asymmetric cis induction and its application to the asymmetric synthesis of precursors of β-branched unusual amino acids

AU - Li, Guigen

AU - Patel, Dinesh

AU - Hruby, Victor J.

N1 - Funding Information: Acknowledgment This work has been supportedb y U. S. Public Service Grants, DK 36289 and CA 57723, and NIDA Grants DA 06284 and DA 04248. and SRSF GraduateS cholarship (University of Arizona, GLi172317).We would like to thank Dr. Michael Bruck for the X-ray structure analysis, Dr. Robin Polt for the helpful discussions.a nd Dr. B.-S. Lou for her assistance.

PY - 1994/4/11

Y1 - 1994/4/11

N2 - A new method for the asymmetric synthesis of key intermediates of unusual amino acids has been established by utilizing β-carbon chirality for asymmetric induction in allylic-strained boron enolates.

AB - A new method for the asymmetric synthesis of key intermediates of unusual amino acids has been established by utilizing β-carbon chirality for asymmetric induction in allylic-strained boron enolates.

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U2 - 10.1016/0040-4039(94)85204-9

DO - 10.1016/0040-4039(94)85204-9

M3 - Article

AN - SCOPUS:0028327552

SN - 0040-4039

VL - 35

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 15

ER -

1, 2-Asymmetric cis induction and its application to the asymmetric synthesis of precursors of β-branched unusual amino acids

Abstract

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