一种 N-杂环卡宾催化合成氘代苯偶姻的方法

Xinyu Zhang; Huihui Geng; Shilei Zhang; Wei Wang; Xiaobei Chen

doi:10.6023/cjoc202210005

一种 N-杂环卡宾催化合成氘代苯偶姻的方法

Translated title of the contribution: A Method for the Synthesis of Deuterated Benzoins Catalyzed by N-Heterocyclic Carbene

Xinyu Zhang, Huihui Geng, Shilei Zhang, Wei Wang, Xiaobei Chen

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

An efficient method has been developed for the synthesis of deuterated benzoins from two molecules of aldehydes under the catalysis of N-heterocyclic carbene by using D2O as the deuterium source, providing the products with deuterium selectively incorporated at the α-position of ketone group. The method features simple operation and mild reaction conditions, and a variety of aromatic aldehyde substrates could afford products with high deuterium incorporation.

Translated title of the contribution	A Method for the Synthesis of Deuterated Benzoins Catalyzed by N-Heterocyclic Carbene
Original language	Chinese (Traditional)
Pages (from-to)	1510-1516
Number of pages	7
Journal	Chinese Journal of Organic Chemistry
Volume	43
Issue number	4
DOIs	https://doi.org/10.6023/cjoc202210005
State	Published - Apr 25 2023
Externally published	Yes

Keywords

N-heterocyclic carbene
benzoin condensation
deuteration
deuteroxide
organocatalysis

ASJC Scopus subject areas

Organic Chemistry

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10.6023/cjoc202210005

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title = "一种 N-杂环卡宾催化合成氘代苯偶姻的方法",

abstract = "An efficient method has been developed for the synthesis of deuterated benzoins from two molecules of aldehydes under the catalysis of N-heterocyclic carbene by using D2O as the deuterium source, providing the products with deuterium selectively incorporated at the α-position of ketone group. The method features simple operation and mild reaction conditions, and a variety of aromatic aldehyde substrates could afford products with high deuterium incorporation.",

keywords = "N-heterocyclic carbene, benzoin condensation, deuteration, deuteroxide, organocatalysis",

author = "Xinyu Zhang and Huihui Geng and Shilei Zhang and Wei Wang and Xiaobei Chen",

note = "Publisher Copyright: {\textcopyright} 2023 Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.",

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doi = "10.6023/cjoc202210005",

language = "Chinese (Traditional)",

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T1 - 一种 N-杂环卡宾催化合成氘代苯偶姻的方法

AU - Zhang, Xinyu

AU - Geng, Huihui

AU - Zhang, Shilei

AU - Wang, Wei

AU - Chen, Xiaobei

PY - 2023/4/25

Y1 - 2023/4/25

N2 - An efficient method has been developed for the synthesis of deuterated benzoins from two molecules of aldehydes under the catalysis of N-heterocyclic carbene by using D2O as the deuterium source, providing the products with deuterium selectively incorporated at the α-position of ketone group. The method features simple operation and mild reaction conditions, and a variety of aromatic aldehyde substrates could afford products with high deuterium incorporation.

AB - An efficient method has been developed for the synthesis of deuterated benzoins from two molecules of aldehydes under the catalysis of N-heterocyclic carbene by using D2O as the deuterium source, providing the products with deuterium selectively incorporated at the α-position of ketone group. The method features simple operation and mild reaction conditions, and a variety of aromatic aldehyde substrates could afford products with high deuterium incorporation.

KW - N-heterocyclic carbene

KW - benzoin condensation

KW - deuteration

KW - deuteroxide

KW - organocatalysis

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EP - 1516

JO - Chinese Journal of Organic Chemistry

JF - Chinese Journal of Organic Chemistry

IS - 4

ER -

一种 N-杂环卡宾催化合成氘代苯偶姻的方法

Abstract

Keywords

ASJC Scopus subject areas

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