β-Amino alcohols from amino acids: Chelation control via schiff bases.

Robin Polt; Matt A. Peterson

doi:10.1016/S0040-4039(00)97784-0

β-Amino alcohols from amino acids: Chelation control via schiff bases.

Robin Polt, Matt A. Peterson

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Sequential addition of iBu₂AIH and RLi or RMgX to Schiff base esters derived from amino acids provides a simple route to β-amino alcohols. The reaction procedes without racemization, and with high threo selectivity. Several representative sphingosines are synthesized.

Original language	English (US)
Pages (from-to)	4985-4986
Number of pages	2
Journal	Tetrahedron Letters
Volume	31
Issue number	35
DOIs	https://doi.org/10.1016/S0040-4039(00)97784-0
State	Published - 1990

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)97784-0

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title = "β-Amino alcohols from amino acids: Chelation control via schiff bases.",

abstract = "Sequential addition of iBu2AIH and RLi or RMgX to Schiff base esters derived from amino acids provides a simple route to β-amino alcohols. The reaction procedes without racemization, and with high threo selectivity. Several representative sphingosines are synthesized.",

author = "Robin Polt and Peterson, {Matt A.}",

year = "1990",

doi = "10.1016/S0040-4039(00)97784-0",

language = "English (US)",

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pages = "4985--4986",

journal = "Tetrahedron Letters",

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T2 - Chelation control via schiff bases.

AU - Polt, Robin

AU - Peterson, Matt A.

PY - 1990

Y1 - 1990

N2 - Sequential addition of iBu2AIH and RLi or RMgX to Schiff base esters derived from amino acids provides a simple route to β-amino alcohols. The reaction procedes without racemization, and with high threo selectivity. Several representative sphingosines are synthesized.

AB - Sequential addition of iBu2AIH and RLi or RMgX to Schiff base esters derived from amino acids provides a simple route to β-amino alcohols. The reaction procedes without racemization, and with high threo selectivity. Several representative sphingosines are synthesized.

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U2 - 10.1016/S0040-4039(00)97784-0

DO - 10.1016/S0040-4039(00)97784-0

M3 - Article

AN - SCOPUS:0025003890

SN - 0040-4039

VL - 31

SP - 4985

EP - 4986

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 35

ER -

β-Amino alcohols from amino acids: Chelation control via schiff bases.

Abstract

ASJC Scopus subject areas

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