Survival Signals for Molecular Target Assessment

  • Roe, Denise (PI)
  • Briehl, Margaret M (PI)
  • Taylor, Charles (PI)
  • Whitesell, Luke (PI)
  • Gillies, Robert (PI)
  • List, Alan (PI)
  • Dorr, Robert (PI)
  • Kunkel, Mark (PI)
  • Powis, Garth (PI)

Project: Research project

Grant Details


DESCRIPTION: (provided by applicant)
The target area to be studied in this proposal are the molecular targets
provided by survival (anti-apoptosis) signaling pathways in cancer cells. We
will study six novel cancer drugs that affect these molecular targets. The
goal of the work is to develop more effective ways of preventing and treating
cancer through a knowledge of the effects of new types of molecular targeted
drugs on their specific targets in human cancer. The objectives of the study
are to develop specific, sensitive and robust assays for the molecular target,
to validate them in cellular and animal models, and to use the assays to
measure drug effects on their targets in patient clinical trials. The
information obtained from the studies will be used to design more effective
clinical trials for molecularly targeted drugs. The overarching hypothesis
upon which the study is based is that a pharmacodynamic understanding of the
effects of cancer drugs on survival signaling molecular targets in cancer
cells will lead to improved ways of using these drugs and more effective
therapies for preventing and treating cancer. The program is based upon a
specific class of anticancer drugs but the findings should be generally
applicable to the development of many classes of molecularly targeted cancer
drugs. The work will provide important insights into the way these new types
of agents can be developed and how their clinical trial should be conducted.
Effective start/end date7/1/0112/31/07


  • National Institutes of Health


  • Medicine(all)


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