• Bloom, John W (PI)
  • Sobonya, Richard E (PI)
  • Sherrill, Duane L (PI)
  • Morgan, Wayne J (PI)
  • C George, Ray (PI)
  • [No Value], C. George (PI)
  • Halhonen, Marilyn (PI)
  • Newell, John (PI)
  • Taussig, Lynn (PI)
  • Enright, Paul (PI)
  • Lemen, Richard (PI)
  • Lebowitz, Micheal (PI)
  • Kreulen, David (PI)
  • Knudson, Ronald (PI)
  • Burrows, Benjamin (PI)
  • Halonen, Marilyn (PI)

Project: Research project

Grant Details


The overall objectives of the Arizona SCOR are to determine the
pathogenesis, natural histories, methods of early detection, and possible
means of prevention of airways obstructive diseases (AOD). Nine closely
related epidemiological, physiological, and experimental projects,
supported by four cores provide a coordinated multidisciplinary
interdepartmental program. The data from our longitudinal study of a
general population sample including >1700 households and >4500 subjects
will continue to be analyzed to identify innate and extrinsic risk factors
for the development and progression of AOD. Data will continue to be
collected on selected subsets of this population to maximize follow-up, to
answer specific hypotheses, or to carry out detailed studies of lung
structure and function. The cohort of >1200 newborns and their families
enrolled several years ago will continue to be followed to determine the
importance of inherited characteristics and events in infancy (especially
viral lower respiratory tract illnesses) in determining lung function,
bronchial reactivity, and immunologic status later in life. Detailed
studies of lung growth and respiratory physiology of infants and children
will be continued. The effects of smoke exposure on the developing lung
will be assessed in infants and in an animal model. An already enrolled
population of middle aged working subjects and families with bronchial
hyperresponsiveness (BHR) will continue to be studied, with an emphasis on
relating BHR and other host factors to the development and progression of
airways abnormalities. Our canine model of viral bronchiolitis will be
expanded to determine how induced "allergy" influences the effects of the
viral infection, especially in regard to BR and immunologic status. The
basic mechanisms involved in BR will be studied in vivo in a rabbit model
with many features of allergic asthma and in excised airway preparations.
Since preliminary work suggests an important role of the parasympathetic
system in regulating BR, a detailed study of muscarinic and NANC receptors
in the lung is included as well as a project to study the electrophysiology
of parasympathetic airway ganglia which may be important in modulating
airway function.
Effective start/end date12/1/7611/30/97


  • National Institutes of Health


  • Medicine(all)


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