Project: Research project

Grant Details


Considerable information exists about the metabolism of prostaglandins in
the gastrointestinal tract of adults. Surprisingly, very little is known
about similar processes during early post-natal development, especially in
view of the presence of protaglandins in milk. The proposed studies will
therefore concentrate on comparison of developmental changes in
prostaglandin metabolism in the gastrointestinal tract with emphasis on the
processing of orally administered prostaglandins and the role of
prostaglandins in the immature gastrointestinal tract in normal and
pathological conditions. OBJECTIVES: 1) To determine the prostaglandin content, synthesis, and
degradative capacity of the gastrointestinal tract in rats at various
developmental stages, tissue preparations will be incubated with
radiolabeled arachidonic acid and prostaglandin, followed by isolation of
the formed products of prostaglandin synthesis and degradation respectively. 2) To characterize the processing of orally administered prostaglandin by
the rat gastrointestinal tract, studies will be performed with radiolabeled
prostaglandin with subsequent analysis of intact prostaglandin and
metabolites in the gastrointestinal tract and peripheral organs. 3) To examine the significance and metabolism of prostaglandins in the
gastrointestinal tract in an experimental animal model of neonatal
necrotizing enterocolitis (NEC). Evaluation of prostaglandin metabolism in the immature gastrointestinal
tract will allow a more complete understanding of the physiology of the
newborn intestine and may provide insight into some of the medical problems
relating to nutrition and the gastrointestinal tract in the premature
Effective start/end date9/1/868/31/89


  • National Institutes of Health


  • Medicine(all)


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