• Sterling, Charles R (PI)
  • Garcia, Hector Hugo (PI)
  • Gonzales, Armando (PI)
  • Marshall, Marilyn (PI)
  • Vaisberg, Abrahim (PI)
  • Cordero, Luis (PI)
  • Cabrera, Lillie (PI)
  • Verastegui, Manuela (PI)
  • Gilman, Robert (PI)

    Project: Research project

    Grant Details


    This project examines the role of emerging gastrointestinal pathogens in
    Peru, a developing country. Newer viral agents appear to be important
    causes of childhood diarrhea. Cyclospora cayetanensis, a coccidial
    parasite recently identified by our group, is an important cause of
    disease in children, travelers and AIDS patients. Cysticercosis is an
    important cause of late onset epilepsy and other neurological conditions. The epidemiology or viral diarrhea in our shanty town population will be
    defined using recently developed diagnostic tools for detection of new
    viral agents including astro, enteric adeno, calci, norwalk and toro
    viruses. The importance of secondary rotavirus infection will be
    determined. Cyclospora cayetanensis, is a protozoa recently identified by our group
    and named after the Peruvian university, Cayetano Heredia. Its
    epidemiological role in children's diarrhea, and its seroprevalence will
    be described in a Peruvian shanty town. The antigenic and molecular
    structure of Cyclospora cayetanensis will be further defined. Children
    infected with this parasite will be randomized for treatment in a double
    blind trial to determine if trimethoprim/sulfamethoxazole is an effective
    therapy. New immunological tools for diagnosing cysticercosis will be developed and
    then tested in Peru, a highly endemic zone. Pigs, an intermediate host of
    cysticercosis, will be used as sentinels to predict changes in
    environmental infection with Taenia solium eggs.
    Effective start/end date8/1/947/31/06


    • National Institutes of Health


    • Medicine(all)
    • Immunology and Microbiology(all)


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