Project: Research project

Grant Details


The overall objective of this proposal is to allow the principal
investigator to describe the growth and development of the infant lung in
health and disease. This is pursuant to a long term career goal of
studying infant lung disease, its risk factors and sequelae in order to
define and assess strategies of prevention and treatment. As such the
project is divided into two phases: The first will be the development of
the safe, efficient, and noninvasive techniques needed to study infantile
pulmonary function and the development of airways reactivity. Specific
assessment of methods of standardization, sources of variability and
techniques of digital analysis will be emphasized during this phase. To
accomplish this the investigator proposes to study techniques including the
measurement of forced expiratory flow, forced oscillatory resistance, tidal
flow-volume loop analysis, quasi-static and dynamic pulmonary compliance,
inductive plethysmography and airway challenge with cold air and
ultrasonically nebulized, distilled water. The second phase will lead to
the development of normative data and a prospective description of the
changes in pulmonary physiology during infancy. This will also include the
assessment of a group of infants at high risk for hyper-reactive airways to
determine whether or not such reactivity can be detected prior to the onset
of viral respiratory infection. The investigator will also make use of
techniques in digital data acquisition and analysis in order to maintain a
high level of efficiency and accuracy. The successful completion of this
project will thus give the investigator the expertise and methodologies
necessary to continue a research career assessing acute and chronic
pulmonary disorders during infancy with specific reference to their risk
factors, natural history, sequelae, prevention and treatment.
Effective start/end date3/1/842/28/89


  • National Institutes of Health


  • Medicine(all)


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