• Cress, Anne E (PI)
  • Sim, Dalice (PI)
  • Cetas, Thomas (PI)
  • Cassady, Robert (PI)
  • Gerner, Eugene (PI)

Project: Research project

Grant Details


The objective is to determine the efficacy of hyperthermia in the treatment
of human malignancies when combined with surgery, radiation or
chemotherapy. The research involves a multidisciplinary effort, including
biological, physical, and clinical scientists. Specific aims of the
biological projects within this program are designed to further describe
the underlying biochemical and molecular principles of cellular damage by
hyperthermia which leads to cytotoxicity. The biological projects are
designed to test basic concepts which have potential clinical
applications. The physics and engineering project has the overall goal of
delivering desired therapeutic temperatures to any anatomical site in a
human cancer patient, to document the delivered dose, and to insure patient
safety during treatment. A major subtheme integrates the various basic
science and clinical projects, and is the development of thermal
dosimetry. This subtheme impacts all projects and attempts to, first,
relate time and temperature parameters in a single function and, second,
document these parameters in patients undergoing hyperthermia therapy such
that clinical responses can be correlated with thermal dose. The human
clinical trials component of this program has been designed to ascertain
the efficacy of hyperthermia, either localized, regional or systemic,
combined with radiation or chemotherapeutic drugs in the treatment of
specific malignancies. The major aim of the clinical project is to conduct
site-specific randomized or phase I/II clinical trials. These trials have
been designed with the long term goal of developing potentially curative
therapies for these diseases. Two major classes of trials are proposed,
one investigating the combination of hyperthermia and radiotherapy and the
other studying combinations of hyperthermia and chemotherapy. Diseases in
the former group of trials include stages B2 and C bladder cancer and
advanced (stages III and IV) head and neck cancers. The latter group of
trials will focus on advanced, recurrent ovarian cancers. Thus, this
Program is designed to investigate the basic biological and physical
principles of hyperthermia, in a comprehensive manner and then to determine
the usefulness of this modality in combination with radiation and drugs in
cancer therapy.
Effective start/end date7/1/786/30/90


  • National Institutes of Health


  • Medicine(all)


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