Grant Details
Description
This is a proposal for a new multi-categorical General Clinical Research
Center at the Children's and University Hospitals. This proposal
combines two previously funded GCRCs into a single unit. We plan to
perform studies utilizing inpatient and outpatient and Core Laboratory
facilities at the Children's Hospital GCRC unit with scatter beds at the
University Hospital. This application includes proposals from the
Departments of Pediatrics, Medicine, Surgery, Obstetrics/Gynecology, and
Radiology. Major areas of research include: 1. Pediatric Liver Disease. Studies will define the pathophysiology of
new inborn errors of bile acid metabolism, use ursodeoxycholic acid for
treatment of cholestatic liver disease, and define the mechanism of
growth failure and bone disease in chronic cholestasis. 2. Diabetes Mellitus. Studies will evaluate the relationship between
proinsulin and insulin secretion/sensitivity in noninsulin-dependent
diabetes mellitus, the natural history of diabetic nephropathy, and the
autonomic dysfunction and responsiveness to hypoglycemia during
pregnancy. 3. Bone Disease. Studies will examine the relationship between race and
activity and bone mineralization in infants, the effect of lactation on
calcium homeostasis, and bone mineralization in chronic pediatric
diseases. 4. Growth Hormone. Studies of growth hormone (GH) will include the role
of sexual dimorphism in growth hormone feedback regulation, the use of
GH to promote growth in children with intrauterine growth retardation,
and IGF-1 administration to children with growth hormone insensitivity. 5. Gaucher Disease. Clinical and molecular studies of Gaucher Disease and
treatment with enzyme augmentation will be performed. 6. Cancer Prevention and Treatment. Studies will evaluate the
bioavailability of soy isoflavones which may have specific anti-
neoplastic qualities and use of specific radionuclides in cancer
treatment. 7. Transplantation Immunology. The mechanism by which donor-specific
blood or marrow transfusion favorably affects renal allograft survival
will be evaluated.
Center at the Children's and University Hospitals. This proposal
combines two previously funded GCRCs into a single unit. We plan to
perform studies utilizing inpatient and outpatient and Core Laboratory
facilities at the Children's Hospital GCRC unit with scatter beds at the
University Hospital. This application includes proposals from the
Departments of Pediatrics, Medicine, Surgery, Obstetrics/Gynecology, and
Radiology. Major areas of research include: 1. Pediatric Liver Disease. Studies will define the pathophysiology of
new inborn errors of bile acid metabolism, use ursodeoxycholic acid for
treatment of cholestatic liver disease, and define the mechanism of
growth failure and bone disease in chronic cholestasis. 2. Diabetes Mellitus. Studies will evaluate the relationship between
proinsulin and insulin secretion/sensitivity in noninsulin-dependent
diabetes mellitus, the natural history of diabetic nephropathy, and the
autonomic dysfunction and responsiveness to hypoglycemia during
pregnancy. 3. Bone Disease. Studies will examine the relationship between race and
activity and bone mineralization in infants, the effect of lactation on
calcium homeostasis, and bone mineralization in chronic pediatric
diseases. 4. Growth Hormone. Studies of growth hormone (GH) will include the role
of sexual dimorphism in growth hormone feedback regulation, the use of
GH to promote growth in children with intrauterine growth retardation,
and IGF-1 administration to children with growth hormone insensitivity. 5. Gaucher Disease. Clinical and molecular studies of Gaucher Disease and
treatment with enzyme augmentation will be performed. 6. Cancer Prevention and Treatment. Studies will evaluate the
bioavailability of soy isoflavones which may have specific anti-
neoplastic qualities and use of specific radionuclides in cancer
treatment. 7. Transplantation Immunology. The mechanism by which donor-specific
blood or marrow transfusion favorably affects renal allograft survival
will be evaluated.
| Status | Finished |
|---|---|
| Effective start/end date | 12/30/93 → 11/30/11 |
Funding
- National Institutes of Health
ASJC
- Medicine(all)
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