• Allen, Ronald E (PI)

    Project: Research project

    Grant Details


    Senile muscle atrophy represents one of the major problems associated with
    aging and is characterized by loss of strength and muscle mass. These
    changes restrict the mobility and independence of a growing segment of our
    society. This project will probe the cellular and molecular changes that occur
    during muscle aging. In particular, the function of skeletal muscle
    satellite cells will be evaluated. Satellite cells are the myogenic
    precursor cells that persist in muscle throughout life and function by
    adding new nuclei to existing muscle fibers during muscle hypertrophy and
    by regenerating new fibers following injury. Their ability to proliferate
    and differentiate in response to three important regulatory protein growth
    factors, or hormones, is being studied. These hormones are the two
    insulin-like growth factors (somatomedins) and fibroblast growth factor.
    In vitro techniques have been devised for monitoring the effects of growth
    factors on the proliferation and differentiation of cultured satellite
    cells, and these techniques will be employed to study the normal control of
    satellite cell activity. In addition, age-related changes in the ability
    of satellite cells to respond to these growth factors and changes in their
    growth factor receptor characteristics during aging will be examined. This
    research program is designed to provide fundamental insights into the
    cellular and molecular mechanisms of muscle aging with the ultimate goal of
    contributing toward the alleviation of problems associated with senile
    muscle atrophy.
    Effective start/end date5/1/824/30/91


    • National Institutes of Health


    • Medicine(all)


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