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Collaborations and top research areas from the last five years
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Crosstalk between co-assembling filamentous enzymes
Horton, N., Aug 2024, In: BioEssays. 46, 8, 2400129.Research output: Contribution to journal › Article › peer-review
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DNA Sequence Control of Enzyme Filamentation and Activation of the SgrAI Endonuclease
Ghadirian, N., Morgan, R. D. & Horton, N. C., Feb 6 2024, In: Biochemistry. 63, 3, p. 326-338 13 p.Research output: Contribution to journal › Article › peer-review
2 Link opens in a new tab Scopus citations -
Structures, mechanisms, and kinetic advantages of the SgrAI filament forming mechanism
Horton, N. C. & Lyumkis, D., 2024, In: Critical reviews in biochemistry and molecular biology. 59, 6, p. 363-401 39 p.Research output: Contribution to journal › Review article › peer-review
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Two-metal ion mechanism of DNA cleavage by activated, filamentous SgrAI
Shan, Z., Rivero-Gamez, A., Lyumkis, D. & Horton, N. C., Aug 2024, In: Journal of Biological Chemistry. 300, 8, 107576.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Physachenolide C is a Potent, Selective BET Inhibitor
Zerio, C. J., Sivinski, J., Wijeratne, E. M. K., Xu, Y. M., Ngo, D. T., Ambrose, A. J., Villa-Celis, L., Ghadirian, N., Clarkson, M. W., Zhang, D. D., Horton, N. C., Gunatilaka, A. A. L., Fromme, R. & Chapman, E., Jan 12 2023, In: Journal of Medicinal Chemistry. 66, 1, p. 913-933 21 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Link opens in a new tab Scopus citations
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BUDDING YEAST SEPTIN FILAMENTS: CONFORMATION AND KINETICS OF FILAMENT FORMATION
Horton, N. C. (PI)
Project: Research project
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STRUCTURAL MECHANISMS OF DNA RECOGNITION AND CLEAVAGE BY SEQUENCE SPECIFIC DNA B
Horton, N. C. (PI)
Project: Research project
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STRUCTURAL MECHANISMS OF RECOGNITION AND CATALYSIS BY DNA MODIFYING ENZYMES
Horton, N. C. (PI)
Project: Research project
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STRUCTURE BASED APPROACH TO ISSUES IN ZINC FINGER RECOGNITION
Horton, N. C. (PI)
Project: Research project
Datasets
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Activated SgrAI endonuclease DNA-bound dimer with Ca2+ and intact primary site DNA
Shan, Z. (Contributor), Ghadirian, N. (Contributor), Lyumkis, D. (Contributor) & Horton, N. C. (Contributor), Protein Data Bank (PDB), Dec 1 2021
DOI: 10.2210/pdb7SS5/pdb, https://www.wwpdb.org/pdb?id=pdb_00007ss5
Dataset
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4C3G : cryo-EM structure of activated and oligomeric restriction endonuclease SgrAI
Lyumkis, D. (Contributor), Talley, H. (Contributor), Stewart, A. (Contributor), Shah, S. (Contributor), Park, C. K. (Contributor), Tama, F. (Contributor), Potter, C. S. (Contributor), Carragher, B. (Contributor) & Horton, N. C. (Contributor), RCSB-PDB, 2013
DOI: 10.2210/pdb4c3g/pdb, https://www.rcsb.org/structure/4C3G
Dataset
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3DPG : SgrAI with noncognate DNA bound
Dunten, P. W. (Contributor), Little, E. J. (Contributor) & Horton, N. C. (Contributor), RCSB-PDB, 2008
DOI: 10.2210/pdb3dpg/pdb, https://www.rcsb.org/structure/3DPG
Dataset
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Aart, a six finger zinc finger designed to recognize ANN triplets
Segal, D. J. (Contributor), Crotty, J. W. (Contributor), Bhakta, M. S. (Contributor), Barbas III, C. F. (Contributor) & Horton, N. C. (Contributor), Protein Data Bank (PDB), Oct 3 2006
DOI: 10.2210/pdb2I13/pdb, https://www.wwpdb.org/pdb?id=pdb_00002i13
Dataset
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BD2 domain of human BRD3 bound to Physachenolide C
Zerio, C. J. (Contributor), Sivinski, J. (Contributor), Wijeratne, E. M. K. (Contributor), Xu, Y.-M. (Contributor), Ngo, D. T. (Contributor), Ambrose, A. J. (Contributor), Villa-Celis, L. (Contributor), Ghadirian, N. (Contributor), Clarkson, M. W. (Contributor), Zhang, D. D. (Contributor), Horton, N. C. (Contributor), Gunatilaka, A. A. L. (Contributor), Fromme, R. (Contributor) & Chapman, E. (Contributor), Protein Data Bank (PDB), Jan 11 2023
DOI: 10.2210/pdb7S3P/pdb, https://www.wwpdb.org/pdb?id=pdb_00007s3p
Dataset