Scholarly Works per year
Scholarly Works per year
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Dive into the research topics where Nancy C Horton is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Crosstalk between co-assembling filamentous enzymes
Horton, N., Aug 2024, In: BioEssays. 46, 8, 2400129.Research output: Contribution to journal › Article › peer-review
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DNA Sequence Control of Enzyme Filamentation and Activation of the SgrAI Endonuclease
Ghadirian, N., Morgan, R. D. & Horton, N. C., Feb 6 2024, In: Biochemistry. 63, 3, p. 326-338 13 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Structures, mechanisms, and kinetic advantages of the SgrAI filament forming mechanism
Horton, N. C. & Lyumkis, D., 2024, In: Critical reviews in biochemistry and molecular biology. 59, 6, p. 363-401 39 p.Research output: Contribution to journal › Review article › peer-review
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Two-metal ion mechanism of DNA cleavage by activated, filamentous SgrAI
Shan, Z., Rivero-Gamez, A., Lyumkis, D. & Horton, N. C., Aug 2024, In: Journal of Biological Chemistry. 300, 8, 107576.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Physachenolide C is a Potent, Selective BET Inhibitor
Zerio, C. J., Sivinski, J., Wijeratne, E. M. K., Xu, Y. M., Ngo, D. T., Ambrose, A. J., Villa-Celis, L., Ghadirian, N., Clarkson, M. W., Zhang, D. D., Horton, N. C., Gunatilaka, A. A. L., Fromme, R. & Chapman, E., Jan 12 2023, In: Journal of Medicinal Chemistry. 66, 1, p. 913-933 21 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations
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STRUCTURAL MECHANISMS OF DNA RECOGNITION AND CLEAVAGE BY SEQUENCE SPECIFIC DNA B
Horton, N. C. (PI)
Project: Research project
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STRUCTURAL MECHANISMS OF DNA RECOGNITION AND CLEAVAGE BY SEQUENCE SPECIFIC DNA B
Horton, N. C. (PI)
Project: Research project
Datasets
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The structure of K92A EcoRV bound to cognate DNA and Mg2+
Horton, N. C. (Contributor) & Perona, J. J. (Contributor), Protein Data Bank (PDB), Apr 6 2004
DOI: 10.2210/pdb1SUZ/pdb, https://www.wwpdb.org/pdb?id=pdb_00001suz
Dataset
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Q138F HincII bound to GTTAAC and cocrystallized with 5 mM Ca2+
Babic, A. C. (Contributor), Little, E. J. (Contributor), Manohar, V. M. (Contributor), Bitinaite, J. (Contributor) & Horton, N. C. (Contributor), Protein Data Bank (PDB), Aug 26 2008
DOI: 10.2210/pdb3E40/pdb, https://www.wwpdb.org/pdb?id=pdb_00003e40
Dataset
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Q138F HincII bound to cleaved DNA (GTT | AAC) and Mn2+
Babic, A. C. (Contributor), Little, E. J. (Contributor), Manohar, V. M. (Contributor), Bitinaite, J. (Contributor) & Horton, N. C. (Contributor), Protein Data Bank (PDB), Aug 26 2008
DOI: 10.2210/pdb3E44/pdb, https://www.wwpdb.org/pdb?id=pdb_00003e44
Dataset
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Domain swapped SgrAI with DNA and calcium bound
Park, C. K. (Contributor), Joshi, H. K. (Contributor), Agrawal, A. (Contributor), Ghare, M. I. (Contributor), Little, E. J. (Contributor), Dunten, P. W. (Contributor), Bitinaite, J. (Contributor) & Horton, N. C. (Contributor), Protein Data Bank (PDB), Nov 10 2010
DOI: 10.2210/pdb3MQ6/pdb, https://www.wwpdb.org/pdb?id=pdb_00003mq6
Dataset
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HincII bound to cleaved, cognate DNA containing GTCGAC
Etzkorn, C. (Contributor) & Horton, N. C. (Contributor), Protein Data Bank (PDB), Sep 28 2004
DOI: 10.2210/pdb1XHU/pdb, https://www.wwpdb.org/pdb?id=pdb_00001xhu
Dataset