Scholarly Works per year
Scholarly Works per year
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Dive into the research topics where Laurence Hurley is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Structural basis for nucleolin recognition of MYC promoter G-quadruplex
Chen, L., Dickerhoff, J., Zheng, K. W., Erramilli, S., Feng, H., Wu, G., Onel, B., Chen, Y., Wang, K. B., Carver, M., Lin, C., Sakai, S., Wan, J., Vinson, C., Hurley, L., Kossiakoff, A. A., Deng, N., Bai, Y., Noinaj, N. & Yang, D., Apr 18 2025, In: Science (New York, N.Y.). 388, 6744, p. eadr1752Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
A synthetic lethal approach to drug targeting of G-quadruplexes based on CX-5461
Jin, M., Hurley, L. H. & Xu, H., Jul 15 2023, In: Bioorganic and Medicinal Chemistry Letters. 91, 129384.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
A first-in-class clinical G-quadruplex-targeting drug. The bench-to-bedside translation of the fluoroquinolone QQ58 to CX-5461 (Pidnarulex)
Xu, H. & Hurley, L. H., Dec 1 2022, In: Bioorganic and Medicinal Chemistry Letters. 77, 129016.Research output: Contribution to journal › Review article › peer-review
45 Scopus citations -
Quindoline-derivatives display potent G-quadruplex-mediated antiviral activity against herpes simplex virus 1
Frasson, I., Soldà, P., Nadai, M., Tassinari, M., Scalabrin, M., Gokhale, V., Hurley, L. H. & Richter, S. N., Dec 2022, In: Antiviral Research. 208, 105432.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
The role of G-Quadruplex DNA in Paraspeckle formation in cancer
Bhatt, U., Kretzmann, A. L., Guédin, A., Ou, A., Kobelke, S., Bond, C. S., Evans, C. W., Hurley, L. H., Mergny, J. L., Iyer, K. S., Fox, A. H. & Smith, N. M., Nov 2021, In: Biochimie. 190, p. 124-131 8 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations
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DNA Quadruplex Control of hTERT Transcription: A New Therapy for Taxotere Resistant Prostate Cancer
Miranti, C. (CoPI) & Hurley, L. (PI)
Project: Research project
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DRUG TARGETING OF G-QUADRAPLEX-NM23-H2 COMPLEX IN THE c-MYC PROMOTER
Hurley, L. (PI)
Project: Research project
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DNA Quadruplex Control of hTERT Transcription: A New Therapy for Taxotere Resistant Prostate Cancer
Hurley, L. (PI)
Project: Research project
Datasets
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In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells
Montoya, J. J. (Creator), Turnidge, M. A. (Creator), Wai, D. H. (Creator), Patel, A. R. (Contributor), Lee, D. W. (Creator), Gokhale, V. (Creator), Hurley, L. H. (Creator), Arceci, R. J. (Creator), Wetmore, C. (Creator) & Azorsa, D. O. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4799331.v1, https://springernature.figshare.com/collections/In_vitro_activity_of_a_G-quadruplex-stabilizing_small_molecule_that_synergizes_with_Navitoclax_to_induce_cytotoxicity_in_acute_myeloid_leukemia_cells/4799331/1
Dataset
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Quindoline/G-quadruplex complex
Dai, J. (Contributor), Carver, M. (Contributor), Hurley, L. H. (Contributor) & Yang, D. (Contributor), Protein Data Bank (PDB), Nov 9 2011
DOI: 10.2210/pdb2L7V/pdb, https://www.wwpdb.org/pdb?id=pdb_00002l7v
Dataset
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In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells
Montoya, J. J. (Creator), Turnidge, M. A. (Creator), Wai, D. H. (Creator), Patel, A. R. (Contributor), Lee, D. W. (Creator), Gokhale, V. (Creator), Hurley, L. H. (Creator), Arceci, R. J. (Creator), Wetmore, C. (Creator) & Azorsa, D. O. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4799331, https://springernature.figshare.com/collections/In_vitro_activity_of_a_G-quadruplex-stabilizing_small_molecule_that_synergizes_with_Navitoclax_to_induce_cytotoxicity_in_acute_myeloid_leukemia_cells/4799331
Dataset
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Crystal structure of the NM23-H2 transcription factor complex with dinucleotide d(AG)
Dexheimer, T. S. (Contributor), Carey, S. S. (Contributor), Zuohe, S. (Contributor), Gokhale, V. M. (Contributor), Hu, X. (Contributor), Murata, L. B. (Contributor), Maes, E. M. (Contributor), Weichsel, A. (Contributor), Sun, D. (Contributor), Meuillet, E. J. (Contributor), Montfort, W. R. (Contributor), Hurley, L. H. (Contributor), Moréra, S. (Contributor), Lacombe, M.-L. (Contributor), Yingwu, X. (Contributor) & Joël Janin, G. L. A. (Contributor), Protein Data Bank (PDB), Sep 23 2008
DOI: 10.2210/pdb3BBB/pdb, https://www.wwpdb.org/pdb?id=pdb_00003bbb
Dataset
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Crystal structure of R88A mutant of the NM23-H2 transcription factor
Dexheimer, T. S. (Contributor), Carey, S. S. (Contributor), Zuohe, S. (Contributor), Gokhale, V. M. (Contributor), Hu, X. (Contributor), Murata, L. B. (Contributor), Maes, E. M. (Contributor), Weichsel, A. (Contributor), Sun, D. (Contributor), Meuillet, E. J. (Contributor), Montfort, W. R. (Contributor), Hurley, L. H. (Contributor), Moréra, S. (Contributor), Lacombe, M.-L. (Contributor), Yingwu, X. (Contributor) & Joël Janin, G. L. A. (Contributor), Protein Data Bank (PDB), Sep 23 2008
DOI: 10.2210/pdb3BBC/pdb, https://www.wwpdb.org/pdb?id=pdb_00003bbc
Dataset