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Collaborations and top research areas from the last five years
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Titin's P-zone domains A164-167 are essential for thick filament structural arrangement
Hoover Browne, C., Han, S. W., Farman, G. P., Smith, J. E., Kolb, J., Gohlke, J., Langlais, P. R., Tonino, P., Methawasin, M., van der Pijl, R. & Granzier, H., May 4 2026, In: The Journal of general physiology. 158, 3Research output: Contribution to journal › Article › peer-review
Open Access -
An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency
Methawasin, M., Strom, J., Marino, V. A., Gohlke, J., Muldoon, J., Herrick, S. R., van der Piji, R., Konhilas, J. P. & Granzier, H., Apr 2025, In: American Journal of Physiology - Heart and Circulatory Physiology. 328, 4, p. H719-H733Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Scopus citations -
Corrigendum: An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency (Am J Physiol Heart Circ Physiol (2025) 328 (H719–H733) DOI: 10.1152/ajpheart.00575.2024)
Methawasin, M., Strom, J., Marino, V. A., Gohlke, J., Muldoon, J., Herrick, S. R., van der Pijl, R., Konhilas, J. P. & Granzier, H., Jul 2025, In: American Journal of Physiology - Heart and Circulatory Physiology. 329, 1, p. H213Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Differential sex-dependent susceptibility to diastolic dysfunction and arrhythmia in cardiomyocytes from obese diabetic heart failure with preserved ejection fraction model
Hernandez, J. M., Shen, E. Y., Ko, C. Y., Hourani, Z., Spencer, E. R., Smoliarchuk, D., Bossuyt, J., Granzier, H., Bers, D. M. & Hegyi, B., Jan 1 2025, In: Cardiovascular Research. 121, 2, p. 254-266 13 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Link opens in a new tab Scopus citations -
Discovery of Titin and Its Role in Heart Function and Disease
Granzier, H. L. & Labeit, S., Jan 3 2025, In: Circulation research. 136, 1, p. 135-157 23 p.Research output: Contribution to journal › Review article › peer-review
22 Link opens in a new tab Scopus citations
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ROLE OF TITIN IN FUNCTIONAL TRANSITIONS DURING MUSCLE DEVELOPMENT AND AGING
Granzier, H. L. (PI)
Project: Research project
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Role of the giant protein titin in cardiac health and disease
Granzier, H. L. (CoPI) & Granzier, H. L. (PI)
Project: Research project
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Roles of Nebulin in Structure and Function of Striated Muscle
Granzier, H. L. (PI)
Project: Research project
Datasets
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Partial deletion of titin's C-zone alters cardiac function by reducing the operating sarcomere length range
Farman, G. P. (Creator), Granzier-Nakajima, S. (Creator), Strom, J. (Creator), Kiss, B. (Creator), Smith, J. E. (Creator), Granzier, H. (Creator) & Methawasin, M. (Creator), University of Arizona Research Data Repository, 2023
DOI: 10.25422/azu.data.22239415, https://arizona.figshare.com/articles/dataset/Partial_deletion_of_titin_s_C-zone_alters_cardiac_function_by_reducing_the_operating_sarcomere_length_range/22239415
Dataset
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Supplementary material from "Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I"
Bogomolovas, J. (Creator), Fleming, J. R. (Creator), Anderson, B. R. (Creator), Williams, R. (Creator), Lange, S. (Creator), Simon, B. (Creator), Khan, M. M. (Contributor), Rudolf, R. (Creator), Franke, B. (Creator), Bullard, B. (Creator), Rigden, D. J. (Creator), Granzier, H. (Creator), Labeit, S. (Creator) & Mayans, O. (Creator), figshare, 2016
DOI: 10.6084/m9.figshare.c.3469731.v1, https://figshare.com/collections/Supplementary_material_from_Exploration_of_pathomechanisms_triggered_by_a_single-nucleotide_polymorphism_in_titin_s_I-band_the_cardiomyopathy-linked_mutation_T2580I_/3469731/1
Dataset
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Supplementary information files for NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy Item
Ranu, N. (Creator), Laitila, J. (Creator), Dugdale, H. F. (Creator), Mariano, J. (Creator), Kolb, J. S. (Creator), Wallgren-Pettersson, C. (Contributor), Witting, N. (Creator), Vissing, J. (Creator), Vilchez, J. J. (Creator), Fiorillo, C. (Creator), Zanoteli, E. (Creator), Auranen, M. (Creator), Jokela, M. (Creator), Tasca, G. (Creator), Claeys, K. G. (Creator), Voermans, N. C. (Creator), Palmio, J. (Creator), Huovinen, S. (Creator), Moggio, M. (Creator), Beck, T. N. (Creator), Kontrogianni-Konstantopoulos, A. (Contributor), Granzier, H. (Creator) & Ochala, J. (Creator), Loughborough University, 2023
DOI: 10.17028/rd.lboro.22761185.v1, https://repository.lboro.ac.uk/articles/dataset/Supplementary_information_files_for_NEB_mutations_disrupt_the_super-relaxed_state_of_myosin_and_remodel_the_muscle_metabolic_proteome_in_nemaline_myopathy_Item/22761185/1
Dataset
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Crystal structure of domain I10 from titin in space group P212121
Bogomolovas, J. (Contributor), Fleming, J. R. (Contributor), Anderson, B. R. (Contributor), Williams, R. (Contributor), Lange, S. (Contributor), Simon, B. (Contributor), Khan, M. M. (Contributor), Rudolf, R. (Contributor), Franke, B. (Contributor), Bullard, B. (Contributor), Rigden, D. J. (Contributor), Granzier, H. (Contributor), Labeit, S. (Contributor) & Mayans, O. (Contributor), Protein Data Bank (PDB), Aug 17 2016
DOI: 10.2210/pdb5JDJ/pdb, https://www.wwpdb.org/pdb?id=pdb_00005jdj
Dataset
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Crystal structure of I9-I11 tandem from titin (P1)
Bogomolovas, J. (Contributor), Fleming, J. R. (Contributor), Anderson, B. R. (Contributor), Williams, R. (Contributor), Lange, S. (Contributor), Simon, B. (Contributor), Khan, M. M. (Contributor), Rudolf, R. (Contributor), Franke, B. (Contributor), Bullard, B. (Contributor), Rigden, D. J. (Contributor), Granzier, H. (Contributor), Labeit, S. (Contributor) & Mayans, O. (Contributor), Protein Data Bank (PDB), Sep 14 2016
DOI: 10.2210/pdb5JDE/pdb, https://www.wwpdb.org/pdb?id=pdb_00005jde
Dataset