Scholarly Works per year
Scholarly Works per year
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Dive into the research topics where Gregory Thatcher is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors
Cabel, C. R., Guzman, B. A., Alizadeh, E., Li, S., Holberg, C., Wichaidit, C., Cusanovich, D. A., Paek, A. L., Thatcher, G. R. J., Van Doorslaer, K., Nargi, R. S., Sutton, R. E., Suryadevara, N., Crowe, J. E., Carnahan, R. H., Campos, S. K. & Thorne, C. A., 2025, In: Frontiers in Cell and Developmental Biology. 13, 1538934.Research output: Contribution to journal › Article › peer-review
Open Access -
Development of a high-throughput TR-FRET assay to identify inhibitors of the FAK-paxillin protein-protein interaction
Aromokeye, R., Ackerman-Berrier, M., Araujo, R. D. C., Lambousis, M., Cardoza, S., Chen, L. C., Kaplan, M. E., Zhu, H., Zerbinatti, C., Penton, C., Thatcher, G. R. J. & Marlowe, T., Jul 2025, In: SLAS Discovery. 34, 100237.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and Death
Velma, G. R., Krider, I. S., Alves, E. T. M., Courey, J. M., Laham, M. S. & Thatcher, G. R. J., Apr 25 2024, In: Journal of Medicinal Chemistry. 67, 8, p. 5999-6026 28 p.Research output: Contribution to journal › Review article › peer-review
Open Access6 Scopus citations -
Estradiol improves behavior in FAD transgenic mice that express APOE3 but not APOE4 after ovariectomy
Balu, D., Valencia-Olvera, A. C., Deshpande, A., Narayanam, S., Konasani, S., Pattisapu, S., York, J. M., Thatcher, G. R. J., LaDu, M. J. & Tai, L. M., 2024, In: Frontiers in Endocrinology. 15, 1374825.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress
Gordon-Blake, J., Ratia, K., Weidig, V., Velma, G. R., Ackerman-Berrier, M., Penton, C., Musku, S. R., Alves, E. T. M., Driver, T., Tai, L. & Thatcher, G. R. J., Feb 8 2024, In: ACS Medicinal Chemistry Letters. 15, 2, p. 205-214 10 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations
Grants
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Nomethiazoles harnessing GABA and NO mimetic activity for Alzheimer's therapy
Thatcher, G. (PI) & Thatcher, G. (PI)
Project: Research project
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Identification of preclinical drug candidates for the treatment of schistosomiasis
Thatcher, G. (CoPI)
Project: Research project
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Identification of preclinical drug candidates for the treatment of schistosomiasis
Thatcher, G. (CoPI) & Thatcher, G. (CoPI)
Project: Research project
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Partial Agonists at Estrogen Receptor alpha for Breast Cancer Therapy
Thatcher, G. (PI) & Thatcher, G. (PI)
Project: Research project
Datasets
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SARS-CoV-2 papain-like protease (PLpro) bound to inhibitor XR8-69
Shen, Z. (Contributor), Ratia, K. (Contributor), Cooper, L. (Contributor), Kong, D. (Contributor), Lee, H. (Contributor), Kwon, Y. (Contributor), Li, Y. (Contributor), Alqarni, S. (Contributor), Huang, F. (Contributor), Dubrovskyi, O. (Contributor), Rong, L. (Contributor), Thatcher, G. (Contributor) & Xiong, R. (Contributor), Protein Data Bank (PDB), Feb 24 2021
DOI: 10.2210/pdb7LLZ/pdb, https://www.wwpdb.org/pdb?id=pdb_00007llz
Dataset
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Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 4-Aminopiazthiole
Fata, F. (Contributor), Silvestri, I. (Contributor), Ardini, M. (Contributor), Ippoliti, R. (Contributor), Di Leandro, L. (Contributor), Demitri, N. (Contributor), Polentarutti, M. (Contributor), Di Matteo, A. (Contributor), Lyu, H. (Contributor), Thatcher, G. R. J. (Contributor), Petukhov, P. A. (Contributor), Williams, D. L. (Contributor) & Angelucci, F. (Contributor), Protein Data Bank (PDB), May 19 2021
DOI: 10.2210/pdb6ZLP/pdb, https://www.wwpdb.org/pdb?id=pdb_00006zlp
Dataset
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Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 3-(3-methoxyquinoxalin-2-yl)propanoic acid
Fata, F. (Contributor), Silvestri, I. (Contributor), Ardini, M. (Contributor), Ippoliti, R. (Contributor), Di Leandro, L. (Contributor), Demitri, N. (Contributor), Polentarutti, M. (Contributor), Di Matteo, A. (Contributor), Lyu, H. (Contributor), Thatcher, G. R. J. (Contributor), Petukhov, P. A. (Contributor), Williams, D. L. (Contributor) & Angelucci, F. (Contributor), Protein Data Bank (PDB), May 19 2021
DOI: 10.2210/pdb6ZST/pdb, https://www.wwpdb.org/pdb?id=pdb_00006zst
Dataset
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Human NAMPT in complex with substrate NAM
Ratia, K. M. (Contributor), Shen, Z. (Contributor), Gordon-Blake, J. (Contributor), Lee, H. (Contributor), Laham, M. S. (Contributor), Krider, I. S. (Contributor), Christie, N. (Contributor), Ackerman-Berrier, M. (Contributor), Penton, C. (Contributor), Knowles, N. G. (Contributor), Musku, S. R. (Contributor), Fu, J. (Contributor), Velma, G. R. (Contributor), Xiong, R. (Contributor) & Thatcher, G. R. J. (Contributor), Protein Data Bank (PDB), Mar 8 2023
DOI: 10.2210/pdb8DSI/pdb, https://www.wwpdb.org/pdb?id=pdb_00008dsi
Dataset
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Human NAMPT in complex with substrate NAM and small molecule activator NP-A1-R
Ratia, K. M. (Contributor), Shen, Z. (Contributor), Gordon-Blake, J. (Contributor), Lee, H. (Contributor), Laham, M. S. (Contributor), Krider, I. S. (Contributor), Christie, N. (Contributor), Ackerman-Berrier, M. (Contributor), Penton, C. (Contributor), Knowles, N. G. (Contributor), Musku, S. R. (Contributor), Fu, J. (Contributor), Velma, G. R. (Contributor), Xiong, R. (Contributor) & Thatcher, G. R. J. (Contributor), Protein Data Bank (PDB), Mar 8 2023
DOI: 10.2210/pdb8DSC/pdb, https://www.wwpdb.org/pdb?id=pdb_00008dsc
Dataset