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Collaborations and top research areas from the last five years
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Discovery of the SARS-CoV-2 Papain-Like Protease Inhibitor MR1–114: From Structure-Based Design to In Vivo Antiviral Efficacy
Gannarapu, M. R., Indukuri, D., Holberg, C., Ratia, K., Ramos, O. L., Cardoza, S., Velma, G. R., Musku, S. R., Qi, Z., Slilaty, S., Li, Z., Rong, L., Thatcher, G. R. J. & Xiong, R., Apr 9 2026, In: Journal of Medicinal Chemistry. 69, 7, p. 8433-8450 18 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Proof-of-concept study: APOE4 brain endothelial cells as a phenotypic compound screen
Valencia-Olvera, A. C., Marottoli, F. M., Ratia, K., Thatcher, G. R. J. & Tai, L. M., Dec 2026, In: Alzheimer's Research and Therapy. 18, 1, 54.Research output: Contribution to journal › Article › peer-review
Open Access -
Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors
Cabel, C. R., Guzman, B. A., Alizadeh, E., Li, S., Holberg, C., Wichaidit, C., Cusanovich, D. A., Paek, A. L., Thatcher, G. R. J., Van Doorslaer, K., Nargi, R. S., Sutton, R. E., Suryadevara, N., Crowe, J. E., Carnahan, R. H., Campos, S. K. & Thorne, C. A., 2025, In: Frontiers in Cell and Developmental Biology. 13, 1538934.Research output: Contribution to journal › Article › peer-review
Open Access -
Development of a high-throughput TR-FRET assay to identify inhibitors of the FAK-paxillin protein-protein interaction
Aromokeye, R., Ackerman-Berrier, M., Araujo, R. D. C., Lambousis, M., Cardoza, S., Chen, L. C., Kaplan, M. E., Zhu, H., Zerbinatti, C., Penton, C., Thatcher, G. R. J. & Marlowe, T., Jul 2025, In: SLAS Discovery. 34, 100237.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and Death
Velma, G. R., Krider, I. S., Alves, E. T. M., Courey, J. M., Laham, M. S. & Thatcher, G. R. J., Apr 25 2024, In: Journal of Medicinal Chemistry. 67, 8, p. 5999-6026 28 p.Research output: Contribution to journal › Review article › peer-review
Open Access11 Link opens in a new tab Scopus citations
Grants
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Partial Agonists at Estrogen Receptor alpha for Breast Cancer Therapy
Thatcher, G. (PI) & Thatcher, G. (PI)
Project: Research project
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Biointeractions of Antiestrogens with Nitric Oxide
Thatcher, G. (PI) & Thatcher, G. (PI)
Project: Research project
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Nitric Oxide Chimera Drugs for Colon Cancer Chemoprevention
Thatcher, G. (PI)
Project: Research project
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Nitric oxide mimetic NSAIDs for treatment of Alzheimer's Disease
Thatcher, G. (PI) & Thatcher, G. (PI)
Project: Research project
Datasets
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Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 3-(3-methoxyquinoxalin-2-yl)propanoic acid
Fata, F. (Contributor), Silvestri, I. (Contributor), Ardini, M. (Contributor), Ippoliti, R. (Contributor), Di Leandro, L. (Contributor), Demitri, N. (Contributor), Polentarutti, M. (Contributor), Di Matteo, A. (Contributor), Lyu, H. (Contributor), Thatcher, G. R. J. (Contributor), Petukhov, P. A. (Contributor), Williams, D. L. (Contributor) & Angelucci, F. (Contributor), Protein Data Bank (PDB), May 19 2021
DOI: 10.2210/pdb6ZST/pdb, https://www.wwpdb.org/pdb?id=pdb_00006zst
Dataset
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Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid
Fata, F. (Contributor), Silvestri, I. (Contributor), Ardini, M. (Contributor), Ippoliti, R. (Contributor), Di Leandro, L. (Contributor), Demitri, N. (Contributor), Polentarutti, M. (Contributor), Di Matteo, A. (Contributor), Lyu, H. (Contributor), Thatcher, G. R. J. (Contributor), Petukhov, P. A. (Contributor), Williams, D. L. (Contributor) & Angelucci, F. (Contributor), Protein Data Bank (PDB), May 19 2021
DOI: 10.2210/pdb7B02/pdb, https://www.wwpdb.org/pdb?id=pdb_00007b02
Dataset
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SARS-CoV-2 papain-like protease (PLpro) bound to inhibitor XR8-24
Shen, Z. (Contributor), Ratia, K. (Contributor), Cooper, L. (Contributor), Kong, D. (Contributor), Lee, H. (Contributor), Kwon, Y. (Contributor), Li, Y. (Contributor), Alqarni, S. (Contributor), Huang, F. (Contributor), Dubrovskyi, O. (Contributor), Rong, L. (Contributor), Thatcher, G. (Contributor) & Xiong, R. (Contributor), Protein Data Bank (PDB), Feb 24 2021
DOI: 10.2210/pdb7LBS/pdb, https://www.wwpdb.org/pdb?id=pdb_00007lbs
Dataset
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CBP bromodomain complexed with YF2-23
Li, Y. (Contributor), Zhao, J. (Contributor), Gutgesell, L. M. (Contributor), Shen, Z. (Contributor), Ratia, K. (Contributor), Dye, K. (Contributor), Dubrovskyi, O. (Contributor), Zhao, H. (Contributor), Huang, F. (Contributor), Tonetti, D. A. (Contributor), Thatcher, G. R. J. (Contributor), Xiong, R. (Contributor), Principe, D. R. (Contributor), Pham, T. N. D. (Contributor), Kamath, S. D. (Contributor), Thummuri, D. (Contributor), Daohong, Z. (Contributor), Underwood, P. W. (Contributor), Trevino, J. (Contributor), Munshi, H. G. (Contributor) & Rana, A. (Contributor), Protein Data Bank (PDB), Sep 1 2021
DOI: 10.2210/pdb7JUO/pdb, https://www.wwpdb.org/pdb?id=pdb_00007juo
Dataset
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Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with TTC-352 and GRIP Peptide
Abderrahman, B. (Contributor), Maximov, P. Y. (Contributor), Curpan, R. F. (Contributor), Fanning, S. W. (Contributor), Hanspal, J. S. (Contributor), Fan, P. (Contributor), Foulds, C. E. (Contributor), Chen, Y. (Contributor), Malovannaya, A. (Contributor), Jain, A. (Contributor), Xiong, R. (Contributor), Greene, G. L. (Contributor), Tonetti, D. A. (Contributor), Thatcher, G. R. J. (Contributor) & Jordan, V. C. (Contributor), Protein Data Bank (PDB), Nov 25 2020
DOI: 10.2210/pdb7JHD/pdb, https://www.wwpdb.org/pdb?id=pdb_00007jhd
Dataset