Scholarly Works per year
Scholarly Works per year
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Dive into the research topics where Gregory Thatcher is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Development of a high-throughput TR-FRET assay to identify inhibitors of the FAK-paxillin protein-protein interaction
Aromokeye, R., Ackerman-Berrier, M., Araujo, R. D. C., Lambousis, M., Cardoza, S., Chen, L. C., Kaplan, M. E., Zhu, H., Zerbinatti, C., Penton, C., Thatcher, G. R. J. & Marlowe, T., Jul 2025, In: SLAS Discovery. 34, 100237.Research output: Contribution to journal › Article › peer-review
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Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and Death
Velma, G. R., Krider, I. S., Alves, E. T. M., Courey, J. M., Laham, M. S. & Thatcher, G. R. J., Apr 25 2024, In: Journal of Medicinal Chemistry. 67, 8, p. 5999-6026 28 p.Research output: Contribution to journal › Review article › peer-review
Open Access3 Scopus citations -
Estradiol improves behavior in FAD transgenic mice that express APOE3 but not APOE4 after ovariectomy
Balu, D., Valencia-Olvera, A. C., Deshpande, A., Narayanam, S., Konasani, S., Pattisapu, S., York, J. M., Thatcher, G. R. J., LaDu, M. J. & Tai, L. M., 2024, In: Frontiers in Endocrinology. 15, 1374825.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress
Gordon-Blake, J., Ratia, K., Weidig, V., Velma, G. R., Ackerman-Berrier, M., Penton, C., Musku, S. R., Alves, E. T. M., Driver, T., Tai, L. & Thatcher, G. R. J., Feb 8 2024, In: ACS Medicinal Chemistry Letters. 15, 2, p. 205-214 10 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Structure-Guided Design and Synthesis of Pyridinone-Based Selective Bromodomain and Extra-Terminal Domain (BET)-First Bromodomain (BD1) Inhibitors
Li, Y., Shen, Z., Ratia, K., Zhao, J., Huang, F., Dubrovyskyii, O., Indukuri, D., Fu, J., Lozano Ramos, O., Thatcher, G. R. J. & Xiong, R., Feb 22 2024, In: Journal of Medicinal Chemistry. 67, 4, p. 2712-2731 20 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations
Grants
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Partial Agonists at Estrogen Receptor alpha for Breast Cancer Therapy
Thatcher, G. (PI) & Thatcher, G. (PI)
Project: Research project
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Nomethiazoles Harnessing GABA and NO mimetic activity for Alzheimer's therapy
Thatcher, G. (PI)
Project: Research project
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Potential ApoE Isoform-Specific Detrimental Effects of RXR Agonists in Alzheimer'
Thatcher, G. (CoPI) & Thatcher, G. (CoPI)
Project: Research project
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Nomethiazoles harnessing GABA and NO mimetic activity for Alzheimer's therapy
Thatcher, G. (PI) & Thatcher, G. (PI)
Project: Research project
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Datasets
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Human NAMPT in complex with quercitrin and AMPcP
Ratia, K. M. (Contributor), Shen, Z. (Contributor), Gordon-Blake, J. (Contributor), Lee, H. (Contributor), Laham, M. S. (Contributor), Krider, I. S. (Contributor), Christie, N. (Contributor), Ackerman-Berrier, M. (Contributor), Penton, C. (Contributor), Knowles, N. G. (Contributor), Musku, S. R. (Contributor), Fu, J. (Contributor), Velma, G. R. (Contributor), Xiong, R. (Contributor) & Thatcher, G. R. J. (Contributor), Protein Data Bank (PDB), Mar 8 2023
DOI: 10.2210/pdb8DSH/pdb, https://www.wwpdb.org/pdb?id=pdb_00008dsh
Dataset
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SARS-CoV-2 papain-like protease (PLpro) bound to inhibitor XR8-83
Shen, Z. (Contributor), Ratia, K. (Contributor), Cooper, L. (Contributor), Kong, D. (Contributor), Lee, H. (Contributor), Kwon, Y. (Contributor), Li, Y. (Contributor), Alqarni, S. (Contributor), Huang, F. (Contributor), Dubrovskyi, O. (Contributor), Rong, L. (Contributor), Thatcher, G. (Contributor) & Xiong, R. (Contributor), Protein Data Bank (PDB), Feb 24 2021
DOI: 10.2210/pdb7LLF/pdb, https://www.wwpdb.org/pdb?id=pdb_00007llf
Dataset
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SARS-CoV-2 papain-like protease (PLpro) bound to inhibitor XR8-69
Shen, Z. (Contributor), Ratia, K. (Contributor), Cooper, L. (Contributor), Kong, D. (Contributor), Lee, H. (Contributor), Kwon, Y. (Contributor), Li, Y. (Contributor), Alqarni, S. (Contributor), Huang, F. (Contributor), Dubrovskyi, O. (Contributor), Rong, L. (Contributor), Thatcher, G. (Contributor) & Xiong, R. (Contributor), Protein Data Bank (PDB), Feb 24 2021
DOI: 10.2210/pdb7LLZ/pdb, https://www.wwpdb.org/pdb?id=pdb_00007llz
Dataset
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SARS-CoV-2 papain-like protease (PLpro) bound to inhibitor XR8-89
Shen, Z. (Contributor), Ratia, K. (Contributor), Cooper, L. (Contributor), Kong, D. (Contributor), Lee, H. (Contributor), Kwon, Y. (Contributor), Li, Y. (Contributor), Alqarni, S. (Contributor), Huang, F. (Contributor), Dubrovskyi, O. (Contributor), Rong, L. (Contributor), Thatcher, G. (Contributor) & Xiong, R. (Contributor), Protein Data Bank (PDB), Feb 24 2021
DOI: 10.2210/pdb7LBR/pdb, https://www.wwpdb.org/pdb?id=pdb_00007lbr
Dataset
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Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 2-Methylindole-3-acetic acid
Fata, F. (Contributor), Silvestri, I. (Contributor), Ardini, M. (Contributor), Ippoliti, R. (Contributor), Di Leandro, L. (Contributor), Demitri, N. (Contributor), Polentarutti, M. (Contributor), Di Matteo, A. (Contributor), Lyu, H. (Contributor), Thatcher, G. R. J. (Contributor), Petukhov, P. A. (Contributor), Williams, D. L. (Contributor) & Angelucci, F. (Contributor), Protein Data Bank (PDB), May 19 2021
DOI: 10.2210/pdb6ZP3/pdb, https://www.wwpdb.org/pdb?id=pdb_00006zp3
Dataset