Scholarly Works per year
Scholarly Works per year
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Dive into the research topics where Christopher Hulme is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Discovery and Functional Characterization of a Potent, Selective, and Metabolically Stable PROTAC of the Protein Kinases DYRK1A and DYRK1B
Wilms, G., Schofield, K., Maddern, S., Foley, C., Shaw, Y., Smith, B., Basantes, L. E., Schwandt, K., Babendreyer, A., Chavez, T., McKee, N., Gokhale, V., Kallabis, S., Meissner, F., Rokey, S. N., Dunckley, T., Montfort, W. R., Becker, W. & Hulme, C., Oct 10 2024, In: Journal of Medicinal Chemistry. 67, 19, p. 17259-17289 31 p.Research output: Contribution to journal › Article › peer-review
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DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner
Strine, M. S., Cai, W. L., Wei, J., Alfajaro, M. M., Filler, R. B., Biering, S. B., Sarnik, S., Chow, R. D., Patil, A., Cervantes, K. S., Collings, C. K., DeWeirdt, P. C., Hanna, R. E., Schofield, K., Hulme, C., Konermann, S., Doench, J. G., Hsu, P. D., Kadoch, C. & Yan, Q. & 1 others, , Jun 2023, In: PLoS biology. 21, 6 June, e3002097.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Bedard, N., Coen, A. G., Pekarske, S., Sennett, A., Davis, G. J., Chavez, T., Lichtenberger, D. L. & Hulme, C., Oct 25 2023, In: Tetrahedron Letters. 130, 154748.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity
Zhu, B., Parsons, T., Foley, C., Shaw, Y., Dunckley, T., Hulme, C. & Hodge, J. J. L., Dec 2022, In: Scientific reports. 12, 1, 15847.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Six-Component Reactions and Beyond: The Nuts and Bolts
Hooshmand, S. E., Yazdani, H. & Hulme, C., Sep 13 2022, In: European Journal of Organic Chemistry. 2022, 34, e202200569.Research output: Contribution to journal › Review article › peer-review
6 Scopus citations
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DYRK1A Inhibition as a Novel Treatment Approach for Alzheimer's Disease
Hulme, C. (CoPI) & Hulme, C. (PI)
Project: Research project
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Commercialization of Selective Dyrk1a Inhibitors for Down Syndrome
Hulme, C. (CoPI)
Project: Research project
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Expeditious, biologically driven Pilot Libraries for File Enhancement
Hulme, C. (PI)
Project: Research project
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The Southwest Comprehensive Center for Drug Discovery and Development
Hulme, C. (CoPI)
Project: Research project
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Commercialization of Selective Dyrk1a Inhibitors for Down Syndrome
Hulme, C. (CoPI)
Project: Research project
Datasets
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CCDC 984823: Experimental Crystal Structure Determination
Martinez-Ariza, G. (Creator), Ayaz, M. (Creator), Medda, F. (Creator) & Hulme, C. (Creator), Cambridge Crystallographic Data Centre, 2014
DOI: 10.5517/cc121shd, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc121shd&sid=DataCite
Dataset
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CCDC 962113: Experimental Crystal Structure Determination
Hall, G. B. (Creator), Medda, F. (Creator), Roberts, S. A. (Creator) & Hulme, C. (Creator), Cambridge Crystallographic Data Centre, 2013
DOI: 10.5517/cc1194xd, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc1194xd&sid=DataCite
Dataset
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CCDC 1991579: Experimental Crystal Structure Determination
Schofield, K. (Contributor), Foley, C. (Contributor) & Hulme, C. (Contributor), Cambridge Crystallographic Data Centre, 2020
DOI: 10.5517/ccdc.csd.cc24vdhx, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc24vdhx&sid=DataCite
Dataset
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CCDC 992449: Experimental Crystal Structure Determination
Ayaz, M. (Creator), Xu, Z. (Creator) & Hulme, C. (Creator), Cambridge Crystallographic Data Centre, 2014
DOI: 10.5517/cc129qhl, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc129qhl&sid=DataCite
Dataset
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CCDC 1052077: Experimental Crystal Structure Determination
Martinez-Ariza, G. (Creator), Ayaz, M. (Creator), Roberts, S. A. (Creator), Rabanal-Leõn, W. A. (Contributor), Arratia-Pérez, R. (Creator) & Hulme, C. (Creator), Cambridge Crystallographic Data Centre, 2015
DOI: 10.5517/cc149rz5, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc149rz5&sid=DataCite
Dataset