White-matter-nulled MPRAGE at 7T reveals thalamic lesions and atrophy of specific thalamic nuclei in multiple sclerosis

  • Vincent Planche (Creator)
  • Jason H. Su (Creator)
  • Sandy Mournet (Creator)
  • Manojkumar Saranathan (Contributor)
  • Vincent Dousset (Creator)
  • May Han (Creator)
  • Brian K. Rutt (Creator)
  • Thomas Tourdias (Creator)



Background:Investigating the degeneration of specific thalamic nuclei in multiple sclerosis (MS) remains challenging.Methods:White-matter-nulled (WMn) MPRAGE, MP-FLAIR, and standard T1-weighted magnetic resonance imaging (MRI) were performed on MS patients (n = 15) and matched controls (n = 12). Thalamic lesions were counted in individual sequences and lesion contrast-to-noise ratio (CNR) was measured. Volumes of 12 thalamic nuclei were measured using an automatic segmentation pipeline specifically developed for WMn-MPRAGE.Results:WMn-MPRAGE showed more thalamic MS lesions (n = 35 in 9 out of 15 patients) than MP-FLAIR (n = 25) and standard T1 (n = 23), which was associated with significant improvement of CNR (p p = 0.003) with lower volumes found for the anteroventral (p p p = 0.004) nuclei.Conclusion:WMn-MPRAGE and automatic thalamic segmentation can highlight thalamic MS lesions and measure patterns of focal thalamic atrophy.
Date made available2019

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