Weight loss after Roux-En-Y gastric bypass surgery reveals skeletal muscle DNA methylation changes

  • Luis A. Garcia (Creator)
  • Samantha E. Day (Creator)
  • Richard L. Coletta (Creator)
  • Baltazar Campos (Creator)
  • Tonya R. Benjamin (Creator)
  • Elena A. De Filippis (Creator)
  • James A. Madura (Creator)
  • Lawrence J Mandarino (Creator)
  • Lori R. Roust (Creator)
  • Dawn K Coletta (Creator)



Abstract Background The mechanisms of weight loss and metabolic improvements following bariatric surgery in skeletal muscle are not well known; however, epigenetic modifications are likely to contribute. The aim of our study was to investigate skeletal muscle DNA methylation after weight loss induced by Roux-en-Y gastric bypass (RYGB) surgery. Muscle biopsies were obtained basally from seven insulin-resistant obese (BMI > 40 kg/m2) female subjects (45.1 ± 3.6 years) pre- and 3-month post-surgery with euglycemic hyperinsulinemic clamps to assess insulin sensitivity. Four lean (BMI
Date made available2021

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