Investigations of a combination of atopic status and age of asthma onset identify asthma subphenotypes

  • Huashi Li (Creator)
  • Mario Castro (Creator)
  • Loren C. Denlinger (Creator)
  • Serpil C. Erzurum (Creator)
  • John V. Fahy (Creator)
  • Benjamin Gaston (Creator)
  • Elliot Israel (Creator)
  • Nizar Jarjour (Creator)
  • Bruce D. Levy (Creator)
  • David T. Mauger (Creator)
  • Wendy C. Moore (Creator)
  • Sally E. Wenzel (Creator)
  • Joe G. Zein (Creator)
  • Eugene Bleecker (Creator)
  • Deborah Meyers (Creator)
  • Yin Chen (Creator)
  • Xingnan Li (Creator)



Subphenotypes of asthma may be determined by age onset and atopic status. We sought to characterize early or late onset atopic asthma with fungal or non-fungal sensitization (AAFS or AANFS) and non-atopic asthma (NAA) in children and adults in the Severe Asthma Research Program (SARP). SARP is an ongoing project involving well-phenotyped patients with mild to severe asthma. Phenotypic comparisons were performed using Kruskal-Wallis or chi-square test. Genetic association analyses were performed using logistic or linear regression. Airway hyper-responsiveness, total serum IgE levels, and T2 biomarkers showed an increasing trend from NAA to AANFS and then to AAFS. Children and adults with early onset asthma had greater % of AAFS than adults with late onset asthma (46% and 40% vs. 32%; P 
Date made available2023
PublisherTaylor & Francis

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