Differential vulnerability of thalamic nuclei in multiple sclerosis

  • Simon Blyau (Creator)
  • Ismail Koubiyr (Creator)
  • Manojkumar Saranathan (Creator)
  • Pierrick Coupé (Creator)
  • Mathilde Deloire (Creator)
  • Julie Charré-Morin (Creator)
  • Aurore Saubusse (Creator)
  • Bei Zhang (Creator)
  • Brian K. Rutt (Creator)
  • Vincent Dousset (Creator)
  • B. Brochet (Creator)
  • A. Ruet (Creator)
  • Thomas Tourdias (Creator)



Objectives:Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS).Methods:In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile.Results:T1- and WMn-MPRAGE provided comparable segmentations (0.84 ± 0.13 
Date made available2022
PublisherSAGE Journals

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