Additional file 3 of Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb

  • Jenni M. Laitila (Creator)
  • Elyshia Mcnamara (Contributor)
  • Catherine D. Wingate (Creator)
  • Hayley Goullee (Creator)
  • Jacob A. Ross (Creator)
  • Rhonda L. Taylor (Creator)
  • Robbert van der Pijl (Contributor)
  • Lisa M. Griffiths (Creator)
  • Rachel Harries (Creator)
  • Gianina Ravenscroft (Creator)
  • Joshua S. Clayton (Creator)
  • Caroline A. Sewry (Creator)
  • Michael W. Lawlor (Creator)
  • Coen A C Ottenheijm (Creator)
  • Anthony J. Bakker (Creator)
  • Julien Ochala (Creator)
  • Nigel G. Laing (Creator)
  • Carina Wallgren-Pettersson (Creator)
  • Katarina Pelin (Creator)
  • Kristen J. Nowak (Creator)
  • Kristen Nowak (Creator)

Dataset

Description

Additional file 3. Bodyweight and gross functional changes of NebY2303H,Y935X, NebY935X and NebY2303H mice at 6 months of age. a Female NebY2303H,Y935X and NebY935X mice weighed less (p = 0.017* and p = 0.014*, respectively) than wild-type littermate controls. The functional performance of the mice was tested using whole animal in vivo experiments. b Grip strength testing showed reduced average grip (p = 0.013*) and reduced maximum grip (p = 0.0039**) for the female NebY2303H,Y935X mice. c Female NebY2303H,Y935X mice had impaired performance for three of the four voluntary running wheel measures; distance (p = 0.04*), max speed (p = 0.026*), duration (p = 0.072), and average speed (p = 0.038*). However, no significant differences were demonstrated with the rotarod analyses (data not shown), or for the males in any of the functional tests. Mann-Whitney, *p
Date made available2020
Publisherfigshare

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