Additional file 1 of Exploring the neurobiology of the premonitory phase of migraine preclinically – a role for hypothalamic kappa opioid receptors?

  • Caroline Machado Kopruszinski (Creator)
  • Robson Vizin (Creator)
  • Moe Watanabe (Creator)
  • Ashley L. Martinez (Creator)
  • Luiz Henrique Moreira de Souza (Creator)
  • David W. Dodick (Creator)
  • Frank Porreca (Creator)
  • Edita Navratilova (Creator)
  • David W. Dodick (Creator)



Additional file 1: Supplementary Fig. 1. Systemic administration of the same dose of U-69,593 used in the rat study did not increase water consumption and urination in female mice. Mice were individually placed in metabolic chambers and received a single subcutaneous administration of U-69,593 at 0.56 mg/kg or vehicle-control. (A) Water consumption and (B) volume of urine, as outcome measurements of thirst and polyuria, respectively, were evaluated 120 minutes after treatment. Data are presented as mean ±SEM and analyzed using one-way ANOVA followed by Sidak’s multiple comparison test with * representing p
Date made available2022

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